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Paliperidone Palmitate Associated with Necrotizing Deep Tissue Infection and Sepsis Requiring Surgical Intervention

Long-acting injectable antipsychotics provide the delivery of medication over an extended period of time requiring administration typically only every 2 to 4 weeks. The side effect profile of a long-acting injectable antipsychotic is predictable and similar to the oral formulation. However, injectio...

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Detalles Bibliográficos
Autores principales: Leung, Jonathan G., Kooda, Kirstin J., Frazee, Erin N., Nelson, Sarah, Moore, Katherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710951/
https://www.ncbi.nlm.nih.gov/pubmed/26843999
http://dx.doi.org/10.1155/2015/364325
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author Leung, Jonathan G.
Kooda, Kirstin J.
Frazee, Erin N.
Nelson, Sarah
Moore, Katherine M.
author_facet Leung, Jonathan G.
Kooda, Kirstin J.
Frazee, Erin N.
Nelson, Sarah
Moore, Katherine M.
author_sort Leung, Jonathan G.
collection PubMed
description Long-acting injectable antipsychotics provide the delivery of medication over an extended period of time requiring administration typically only every 2 to 4 weeks. The side effect profile of a long-acting injectable antipsychotic is predictable and similar to the oral formulation. However, injection site reactions may occur with this novel delivery system. The risk of an injection site reaction may be greater with the repeated administration of a lipophilic decanoate formulation and include pain, development of indurations, and fibrosis. Severe complications from injection site reactions have rarely been described in the literature with newer agents. We report the first case of a patient prescribed paliperidone palmitate every 3 weeks that developed severe sepsis requiring vasopressors and intubation due to delayed relayed recognition of a necrotizing infection at an injection site. Clinicians should be alerted to screen for injection site reactions when there is an unknown source infection in a patient receiving a long-acting injectable antipsychotic.
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spelling pubmed-47109512016-02-03 Paliperidone Palmitate Associated with Necrotizing Deep Tissue Infection and Sepsis Requiring Surgical Intervention Leung, Jonathan G. Kooda, Kirstin J. Frazee, Erin N. Nelson, Sarah Moore, Katherine M. Case Rep Psychiatry Case Report Long-acting injectable antipsychotics provide the delivery of medication over an extended period of time requiring administration typically only every 2 to 4 weeks. The side effect profile of a long-acting injectable antipsychotic is predictable and similar to the oral formulation. However, injection site reactions may occur with this novel delivery system. The risk of an injection site reaction may be greater with the repeated administration of a lipophilic decanoate formulation and include pain, development of indurations, and fibrosis. Severe complications from injection site reactions have rarely been described in the literature with newer agents. We report the first case of a patient prescribed paliperidone palmitate every 3 weeks that developed severe sepsis requiring vasopressors and intubation due to delayed relayed recognition of a necrotizing infection at an injection site. Clinicians should be alerted to screen for injection site reactions when there is an unknown source infection in a patient receiving a long-acting injectable antipsychotic. Hindawi Publishing Corporation 2015 2015-12-30 /pmc/articles/PMC4710951/ /pubmed/26843999 http://dx.doi.org/10.1155/2015/364325 Text en Copyright © 2015 Jonathan G. Leung et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Leung, Jonathan G.
Kooda, Kirstin J.
Frazee, Erin N.
Nelson, Sarah
Moore, Katherine M.
Paliperidone Palmitate Associated with Necrotizing Deep Tissue Infection and Sepsis Requiring Surgical Intervention
title Paliperidone Palmitate Associated with Necrotizing Deep Tissue Infection and Sepsis Requiring Surgical Intervention
title_full Paliperidone Palmitate Associated with Necrotizing Deep Tissue Infection and Sepsis Requiring Surgical Intervention
title_fullStr Paliperidone Palmitate Associated with Necrotizing Deep Tissue Infection and Sepsis Requiring Surgical Intervention
title_full_unstemmed Paliperidone Palmitate Associated with Necrotizing Deep Tissue Infection and Sepsis Requiring Surgical Intervention
title_short Paliperidone Palmitate Associated with Necrotizing Deep Tissue Infection and Sepsis Requiring Surgical Intervention
title_sort paliperidone palmitate associated with necrotizing deep tissue infection and sepsis requiring surgical intervention
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710951/
https://www.ncbi.nlm.nih.gov/pubmed/26843999
http://dx.doi.org/10.1155/2015/364325
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