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After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1

Cardiovascular and cerebrovascular ischemic disease is a large class of diseases that is harmful to human health. The primary treatment for the ischemic disease is to recover the blood perfusion and relieve the tissue hypoxia and the shortage of the nutrients in the supply of nutrients. In recent ye...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Niu, Xuehong, Hu, Jihua, Xing, Haijian, Sun, Min, Wang, Juanli, Jian, Qiang, Yang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710957/
https://www.ncbi.nlm.nih.gov/pubmed/26844226
http://dx.doi.org/10.1155/2015/245412
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author Wang, Lei
Niu, Xuehong
Hu, Jihua
Xing, Haijian
Sun, Min
Wang, Juanli
Jian, Qiang
Yang, Hua
author_facet Wang, Lei
Niu, Xuehong
Hu, Jihua
Xing, Haijian
Sun, Min
Wang, Juanli
Jian, Qiang
Yang, Hua
author_sort Wang, Lei
collection PubMed
description Cardiovascular and cerebrovascular ischemic disease is a large class of diseases that is harmful to human health. The primary treatment for the ischemic disease is to recover the blood perfusion and relieve the tissue hypoxia and the shortage of the nutrients in the supply of nutrients. In recent years, investigations found that IGF-1 has a protective effect on cardiovascular disease, especially in myocardial ischemia-reperfusion injury. Investigation into molecular mechanism of ischemia-reperfusion injury may offer potential targets for the development of novel diagnostic strategies. In this study we defined IGF-1 was differentially expressed in the I/R model of the Mus musculus and IGF-1 was the target gene of miR-29a and Let7f. After ischemia-reperfusion, the expression of miR-29a and Let7f increased, while the expression of IGF-1 decreased significantly in the animal model assay. Further studies have found that IGF-1 could inhibit cell apoptosis signaling pathway, thus protecting the reperfusion injury. These results provide new understanding of ischemia-reperfusion injury, with the hope of offering theoretical support for future therapeutic studies.
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spelling pubmed-47109572016-02-03 After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1 Wang, Lei Niu, Xuehong Hu, Jihua Xing, Haijian Sun, Min Wang, Juanli Jian, Qiang Yang, Hua Biomed Res Int Research Article Cardiovascular and cerebrovascular ischemic disease is a large class of diseases that is harmful to human health. The primary treatment for the ischemic disease is to recover the blood perfusion and relieve the tissue hypoxia and the shortage of the nutrients in the supply of nutrients. In recent years, investigations found that IGF-1 has a protective effect on cardiovascular disease, especially in myocardial ischemia-reperfusion injury. Investigation into molecular mechanism of ischemia-reperfusion injury may offer potential targets for the development of novel diagnostic strategies. In this study we defined IGF-1 was differentially expressed in the I/R model of the Mus musculus and IGF-1 was the target gene of miR-29a and Let7f. After ischemia-reperfusion, the expression of miR-29a and Let7f increased, while the expression of IGF-1 decreased significantly in the animal model assay. Further studies have found that IGF-1 could inhibit cell apoptosis signaling pathway, thus protecting the reperfusion injury. These results provide new understanding of ischemia-reperfusion injury, with the hope of offering theoretical support for future therapeutic studies. Hindawi Publishing Corporation 2015 2015-12-30 /pmc/articles/PMC4710957/ /pubmed/26844226 http://dx.doi.org/10.1155/2015/245412 Text en Copyright © 2015 Lei Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Lei
Niu, Xuehong
Hu, Jihua
Xing, Haijian
Sun, Min
Wang, Juanli
Jian, Qiang
Yang, Hua
After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1
title After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1
title_full After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1
title_fullStr After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1
title_full_unstemmed After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1
title_short After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1
title_sort after myocardial ischemia-reperfusion, mir-29a, and let7 could affect apoptosis through regulating igf-1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710957/
https://www.ncbi.nlm.nih.gov/pubmed/26844226
http://dx.doi.org/10.1155/2015/245412
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