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Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study
BACKGROUND: The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one’s subtype-specific breast cancer risk when considering chemoprevention. A number of single nucleotide polymorphisms (SNPs), including one...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711015/ https://www.ncbi.nlm.nih.gov/pubmed/26758508 http://dx.doi.org/10.1186/s12885-015-2036-9 |
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author | Park, Hannah Lui Ziogas, Argyrios Chang, Jenny Desai, Bhumi Bessonova, Leona Garner, Chad Lee, Eunjung Neuhausen, Susan L. Wang, Sophia S. Ma, Huiyan Clague, Jessica Reynolds, Peggy Lacey, James V. Bernstein, Leslie Anton-Culver, Hoda |
author_facet | Park, Hannah Lui Ziogas, Argyrios Chang, Jenny Desai, Bhumi Bessonova, Leona Garner, Chad Lee, Eunjung Neuhausen, Susan L. Wang, Sophia S. Ma, Huiyan Clague, Jessica Reynolds, Peggy Lacey, James V. Bernstein, Leslie Anton-Culver, Hoda |
author_sort | Park, Hannah Lui |
collection | PubMed |
description | BACKGROUND: The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one’s subtype-specific breast cancer risk when considering chemoprevention. A number of single nucleotide polymorphisms (SNPs), including one in caspase-8 (CASP8), have been previously associated with risk of developing breast cancer. Because caspase-8 is an important protein involved in receptor-mediated apoptosis whose activity is affected by estrogen, we hypothesized that additional SNPs in CASP8 could be associated with breast cancer risk, perhaps in a subtype-specific manner. METHODS: Twelve tagging SNPs of CASP8 were analyzed in a nested case control study (1,353 cases and 1,384 controls) of non-Hispanic white women participating in the California Teachers Study. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each SNP using all, estrogen receptor (ER)-positive, ER-negative, human epidermal growth factor receptor 2 (HER2)-positive, and HER2-negative breast cancers as separate outcomes. RESULTS: Several SNPs were associated with all, ER-positive, and HER2-positive breast cancers; however, after correcting for multiple comparisons (i.e., p < 0.0008), only rs2293554 was statistically significantly associated with HER2-positive breast cancer (OR = 1.98, 95 % CI 1.34-2.92, uncorrected p = 0.0005). CONCLUSIONS: While our results for CASP8 SNPs should be validated in other cohorts with subtype-specific information, we conclude that some SNPs in CASP8 are associated with subtype-specific breast cancer risk. This study contributes to our understanding of CASP8 SNPs and breast cancer risk by subtype. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-015-2036-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4711015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47110152016-01-14 Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study Park, Hannah Lui Ziogas, Argyrios Chang, Jenny Desai, Bhumi Bessonova, Leona Garner, Chad Lee, Eunjung Neuhausen, Susan L. Wang, Sophia S. Ma, Huiyan Clague, Jessica Reynolds, Peggy Lacey, James V. Bernstein, Leslie Anton-Culver, Hoda BMC Cancer Research Article BACKGROUND: The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one’s subtype-specific breast cancer risk when considering chemoprevention. A number of single nucleotide polymorphisms (SNPs), including one in caspase-8 (CASP8), have been previously associated with risk of developing breast cancer. Because caspase-8 is an important protein involved in receptor-mediated apoptosis whose activity is affected by estrogen, we hypothesized that additional SNPs in CASP8 could be associated with breast cancer risk, perhaps in a subtype-specific manner. METHODS: Twelve tagging SNPs of CASP8 were analyzed in a nested case control study (1,353 cases and 1,384 controls) of non-Hispanic white women participating in the California Teachers Study. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each SNP using all, estrogen receptor (ER)-positive, ER-negative, human epidermal growth factor receptor 2 (HER2)-positive, and HER2-negative breast cancers as separate outcomes. RESULTS: Several SNPs were associated with all, ER-positive, and HER2-positive breast cancers; however, after correcting for multiple comparisons (i.e., p < 0.0008), only rs2293554 was statistically significantly associated with HER2-positive breast cancer (OR = 1.98, 95 % CI 1.34-2.92, uncorrected p = 0.0005). CONCLUSIONS: While our results for CASP8 SNPs should be validated in other cohorts with subtype-specific information, we conclude that some SNPs in CASP8 are associated with subtype-specific breast cancer risk. This study contributes to our understanding of CASP8 SNPs and breast cancer risk by subtype. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-015-2036-9) contains supplementary material, which is available to authorized users. BioMed Central 2016-01-12 /pmc/articles/PMC4711015/ /pubmed/26758508 http://dx.doi.org/10.1186/s12885-015-2036-9 Text en © Park et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Park, Hannah Lui Ziogas, Argyrios Chang, Jenny Desai, Bhumi Bessonova, Leona Garner, Chad Lee, Eunjung Neuhausen, Susan L. Wang, Sophia S. Ma, Huiyan Clague, Jessica Reynolds, Peggy Lacey, James V. Bernstein, Leslie Anton-Culver, Hoda Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study |
title | Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study |
title_full | Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study |
title_fullStr | Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study |
title_full_unstemmed | Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study |
title_short | Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study |
title_sort | novel polymorphisms in caspase-8 are associated with breast cancer risk in the california teachers study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711015/ https://www.ncbi.nlm.nih.gov/pubmed/26758508 http://dx.doi.org/10.1186/s12885-015-2036-9 |
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