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Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells

BACKGROUND: Hedgehog acyltransferase (Hhat) catalyzes the transfer of the fatty acid palmitate onto Sonic Hedgehog (Shh), a modification that is essential for Shh signaling activity. The Shh signaling pathway has been implicated in the progression of breast cancer. METHODS: To determine the function...

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Detalles Bibliográficos
Autores principales:	Matevossian, Armine, Resh, Marilyn D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711017/ https://www.ncbi.nlm.nih.gov/pubmed/25889650 http://dx.doi.org/10.1186/s12943-015-0345-x

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