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Comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone

BACKGROUND: Head and neck cancer is the third most common cancer in India with 60% presenting in advanced stages. There is the emerging role of neoadjuvant chemotherapy (NACT) in the management of these advanced cancers. There is a general perception that complication rates are higher with the use o...

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Autores principales: Joshi, Poonam, Joshi, Amit, Prabhash, Kumar, Noronha, Vanita, Chaturvedi, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711224/
https://www.ncbi.nlm.nih.gov/pubmed/26811595
http://dx.doi.org/10.4103/0971-5851.171548
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author Joshi, Poonam
Joshi, Amit
Prabhash, Kumar
Noronha, Vanita
Chaturvedi, Pankaj
author_facet Joshi, Poonam
Joshi, Amit
Prabhash, Kumar
Noronha, Vanita
Chaturvedi, Pankaj
author_sort Joshi, Poonam
collection PubMed
description BACKGROUND: Head and neck cancer is the third most common cancer in India with 60% presenting in advanced stages. There is the emerging role of neoadjuvant chemotherapy (NACT) in the management of these advanced cancers. There is a general perception that complication rates are higher with the use of NACT. MATERIALS AND METHODS: This is a retrospectively collected data of head and neck cancer patients operated at our hospital from March 2013 to September 2014. A total of 205 patients were included in the study. These patients were studied in two groups. Group 1 included 153 patients who underwent surgery alone, and Group 2 included 52 patients who received 2-3 cycles of NACT followed by surgery. RESULTS: The mean age of the population was 51 years in the Group 1 and 45 years in Group 2. The hospital stay and readmissions in postoperative period were similar in the two groups. In this study, the complication rate was 37.9% in the surgery patients and 30.8% in the NACT patients (P = 0.424). CONCLUSION: The postoperative complication rates in patients who received NACT followed by surgery were not significantly different from those who underwent surgery.
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spelling pubmed-47112242016-01-25 Comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone Joshi, Poonam Joshi, Amit Prabhash, Kumar Noronha, Vanita Chaturvedi, Pankaj Indian J Med Paediatr Oncol Original Article BACKGROUND: Head and neck cancer is the third most common cancer in India with 60% presenting in advanced stages. There is the emerging role of neoadjuvant chemotherapy (NACT) in the management of these advanced cancers. There is a general perception that complication rates are higher with the use of NACT. MATERIALS AND METHODS: This is a retrospectively collected data of head and neck cancer patients operated at our hospital from March 2013 to September 2014. A total of 205 patients were included in the study. These patients were studied in two groups. Group 1 included 153 patients who underwent surgery alone, and Group 2 included 52 patients who received 2-3 cycles of NACT followed by surgery. RESULTS: The mean age of the population was 51 years in the Group 1 and 45 years in Group 2. The hospital stay and readmissions in postoperative period were similar in the two groups. In this study, the complication rate was 37.9% in the surgery patients and 30.8% in the NACT patients (P = 0.424). CONCLUSION: The postoperative complication rates in patients who received NACT followed by surgery were not significantly different from those who underwent surgery. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4711224/ /pubmed/26811595 http://dx.doi.org/10.4103/0971-5851.171548 Text en Copyright: © Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Joshi, Poonam
Joshi, Amit
Prabhash, Kumar
Noronha, Vanita
Chaturvedi, Pankaj
Comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone
title Comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone
title_full Comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone
title_fullStr Comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone
title_full_unstemmed Comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone
title_short Comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone
title_sort comparison of postoperative complications in advanced head and neck cancer patients receiving neoadjuvant chemotherapy followed by surgery versus surgery alone
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711224/
https://www.ncbi.nlm.nih.gov/pubmed/26811595
http://dx.doi.org/10.4103/0971-5851.171548
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