Cargando…
A d-Amino Acid at the N-Terminus of a Protein Abrogates Its Degradation by the N-End Rule Pathway
[Image: see text] Eukaryotes have evolved the ubiquitin (Ub)/proteasome system to degrade polypeptides. The Ub/proteasome system is one way that cells regulate cytosolic protein and amino acids levels through the recognition and ubiquitination of a protein’s N-terminus via E1, E2, and E3 enzymes. Th...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2015
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711398/ https://www.ncbi.nlm.nih.gov/pubmed/26807441 http://dx.doi.org/10.1021/acscentsci.5b00308 |