Trifluoroacetic acid as excipient destabilizes melittin causing the selective aggregation of melittin within the centrin-melittin-trifluoroacetic acid complexa)

Trifluoroacetic acid (TFA) may be the cause of the bottleneck in high resolution structure determination for protein-peptide complexes. Fragment based drug design often involves the use of synthetic peptides which contain TFA (excipient). Our goal was to explore the effects of this excipient on a mo...

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Detalles Bibliográficos
Autores principales: Pastrana-Rios, Belinda, del Valle Sosa, Liliana, Santiago, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Crystallographic Association 2015
Materias:
SPECIAL TOPIC: BIOLOGY WITH X-RAY LASERS 2
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711628/
https://www.ncbi.nlm.nih.gov/pubmed/26798810
http://dx.doi.org/10.1063/1.4921219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711628/
https://www.ncbi.nlm.nih.gov/pubmed/26798810
http://dx.doi.org/10.1063/1.4921219

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