Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for produc...

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Detalles Bibliográficos
Autores principales: Kirian, R. A., Awel, S., Eckerskorn, N., Fleckenstein, H., Wiedorn, M., Adriano, L., Bajt, S., Barthelmess, M., Bean, R., Beyerlein, K. R., Chavas, L. M. G., Domaracky, M., Heymann, M., Horke, D. A., Knoska, J., Metz, M., Morgan, A., Oberthuer, D., Roth, N., Sato, T., Xavier, P. L., Yefanov, O., Rode, A. V., Küpper, J., Chapman, H. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Crystallographic Association 2015
Materias:
SPECIAL TOPIC: BIOLOGY WITH X-RAY LASERS 2
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711644/
https://www.ncbi.nlm.nih.gov/pubmed/26798816
http://dx.doi.org/10.1063/1.4922648
Descripción
Sumario:A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.

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