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Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption

Arterial stiffening accompanies both aging and atherosclerosis, and age-related stiffening of the arterial intima increases RhoA activity and cell contractility contributing to increased endothelium permeability. Notably, statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibito...

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Detalles Bibliográficos
Autores principales:	Lampi, Marsha C., Faber, Courtney J., Huynh, John, Bordeleau, Francois, Zanotelli, Matthew R., Reinhart-King, Cynthia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712048/ https://www.ncbi.nlm.nih.gov/pubmed/26761203 http://dx.doi.org/10.1371/journal.pone.0147033

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