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Circadian rhythmicity in emerging mood disorders: state or trait marker?

BACKGROUND: Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young people and/or first episode cases of unipolar and bipolar disorders. METHODS: Acti...

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Autores principales: Grierson, Ashlee B., Hickie, Ian B., Naismith, Sharon L., Hermens, Daniel F., Scott, Elizabeth M., Scott, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712181/
https://www.ncbi.nlm.nih.gov/pubmed/26763505
http://dx.doi.org/10.1186/s40345-015-0043-z
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author Grierson, Ashlee B.
Hickie, Ian B.
Naismith, Sharon L.
Hermens, Daniel F.
Scott, Elizabeth M.
Scott, Jan
author_facet Grierson, Ashlee B.
Hickie, Ian B.
Naismith, Sharon L.
Hermens, Daniel F.
Scott, Elizabeth M.
Scott, Jan
author_sort Grierson, Ashlee B.
collection PubMed
description BACKGROUND: Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young people and/or first episode cases of unipolar and bipolar disorders. METHODS: Actigraphy was undertaken for about 14 days in 63 post-pubertal individuals aged 13–25 years with a recent onset of a mood disorder meeting recognised diagnostic criteria. We examined associations between three easily interpretable markers of circadian rhythm activity (amplitude, acrophase and rhythmicity index) and demography and clinical characteristics. Then, circadian markers were compared between diagnostic groups, controlling for potential confounders. RESULTS: Longer duration of illness was correlated with reduced circadian rhythmicity and lower levels of activity over 24 h. A delay in the timing of maximum activity was associated with the level of manic but not depressive symptoms. The circadian rhythmicity index differentiated unipolar from bipolar cases, and in bipolar but not unipolar disorder, the rhythmicity was less robust in those with more severe manic or depressive symptoms. CONCLUSIONS: Less robust circadian rhythmicity, especially associated with increasing symptom severity, may represent a more specific or a trait marker of young people with mood disorders who are at higher risk of a bipolar course of illness.
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spelling pubmed-47121812016-01-19 Circadian rhythmicity in emerging mood disorders: state or trait marker? Grierson, Ashlee B. Hickie, Ian B. Naismith, Sharon L. Hermens, Daniel F. Scott, Elizabeth M. Scott, Jan Int J Bipolar Disord Research BACKGROUND: Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young people and/or first episode cases of unipolar and bipolar disorders. METHODS: Actigraphy was undertaken for about 14 days in 63 post-pubertal individuals aged 13–25 years with a recent onset of a mood disorder meeting recognised diagnostic criteria. We examined associations between three easily interpretable markers of circadian rhythm activity (amplitude, acrophase and rhythmicity index) and demography and clinical characteristics. Then, circadian markers were compared between diagnostic groups, controlling for potential confounders. RESULTS: Longer duration of illness was correlated with reduced circadian rhythmicity and lower levels of activity over 24 h. A delay in the timing of maximum activity was associated with the level of manic but not depressive symptoms. The circadian rhythmicity index differentiated unipolar from bipolar cases, and in bipolar but not unipolar disorder, the rhythmicity was less robust in those with more severe manic or depressive symptoms. CONCLUSIONS: Less robust circadian rhythmicity, especially associated with increasing symptom severity, may represent a more specific or a trait marker of young people with mood disorders who are at higher risk of a bipolar course of illness. Springer Berlin Heidelberg 2016-01-13 /pmc/articles/PMC4712181/ /pubmed/26763505 http://dx.doi.org/10.1186/s40345-015-0043-z Text en © Grierson et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Grierson, Ashlee B.
Hickie, Ian B.
Naismith, Sharon L.
Hermens, Daniel F.
Scott, Elizabeth M.
Scott, Jan
Circadian rhythmicity in emerging mood disorders: state or trait marker?
title Circadian rhythmicity in emerging mood disorders: state or trait marker?
title_full Circadian rhythmicity in emerging mood disorders: state or trait marker?
title_fullStr Circadian rhythmicity in emerging mood disorders: state or trait marker?
title_full_unstemmed Circadian rhythmicity in emerging mood disorders: state or trait marker?
title_short Circadian rhythmicity in emerging mood disorders: state or trait marker?
title_sort circadian rhythmicity in emerging mood disorders: state or trait marker?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712181/
https://www.ncbi.nlm.nih.gov/pubmed/26763505
http://dx.doi.org/10.1186/s40345-015-0043-z
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