PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway

PIWI-interacting RNAs (piRNAs) guide PIWI proteins to suppress transposons in the cytoplasm and nucleus of animal germ cells, but how silencing in the two compartments is coordinated is not known. Here we demonstrate that endonucleolytic slicing of a transcript by the cytosolic mouse PIWI protein MI...

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Detalles Bibliográficos
Autores principales: Yang, Zhaolin, Chen, Kuan-Ming, Pandey, Radha Raman, Homolka, David, Reuter, Michael, Janeiro, Bruno Kotska Rodino, Sachidanandam, Ravi, Fauvarque, Marie-Odile, McCarthy, Andrew A., Pillai, Ramesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712191/
https://www.ncbi.nlm.nih.gov/pubmed/26669262
http://dx.doi.org/10.1016/j.molcel.2015.11.009

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