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Gastrointestinal variant of Lemierre's syndrome complicating ruptured appendicitis

Fusobacterium necrophorum is a non-spore-forming, obligate anaerobic, filamentous, gramnegative bacillus that frequently colonizes the human oral cavity, respiratory tract, and gastrointestinal tract. Fusobacterium species have rarely been implicated in cases of gastrointestinal variant of Lemierre&...

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Autores principales: Akhrass, Fadi Al, Abdallah, Lina, Berger, Steven, Sartawi, Rami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712199/
https://www.ncbi.nlm.nih.gov/pubmed/26793462
http://dx.doi.org/10.1016/j.idcr.2015.07.001
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author Akhrass, Fadi Al
Abdallah, Lina
Berger, Steven
Sartawi, Rami
author_facet Akhrass, Fadi Al
Abdallah, Lina
Berger, Steven
Sartawi, Rami
author_sort Akhrass, Fadi Al
collection PubMed
description Fusobacterium necrophorum is a non-spore-forming, obligate anaerobic, filamentous, gramnegative bacillus that frequently colonizes the human oral cavity, respiratory tract, and gastrointestinal tract. Fusobacterium species have rarely been implicated in cases of gastrointestinal variant of Lemierre's syndrome. We describe a case of F. necrophorum bacteremia associated with suppurative porto-mesenteric vein thrombosis (PVT) following acute ruptured appendicitis. In addition, we list the documented twelve cases of Fusobacterium pylephlebitis. Recanalization of the porto-mesenteric veins and relief of the extrahepatic portal hypertension were achieved with early empiric antibiotic and local thrombolytic therapy. Our patient's case underscores the importance of recognizing Fusobacterium bacteremia as a possible cause of suppurative PVT after disruption of the gastrointestinal mucosa following an acute intraabdominal infectious process. Early treatment of this condition using anticoagulation and endovascular thrombolysis as adjunctive therapies may prevent PVT complications.
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spelling pubmed-47121992016-01-20 Gastrointestinal variant of Lemierre's syndrome complicating ruptured appendicitis Akhrass, Fadi Al Abdallah, Lina Berger, Steven Sartawi, Rami IDCases Case Report Fusobacterium necrophorum is a non-spore-forming, obligate anaerobic, filamentous, gramnegative bacillus that frequently colonizes the human oral cavity, respiratory tract, and gastrointestinal tract. Fusobacterium species have rarely been implicated in cases of gastrointestinal variant of Lemierre's syndrome. We describe a case of F. necrophorum bacteremia associated with suppurative porto-mesenteric vein thrombosis (PVT) following acute ruptured appendicitis. In addition, we list the documented twelve cases of Fusobacterium pylephlebitis. Recanalization of the porto-mesenteric veins and relief of the extrahepatic portal hypertension were achieved with early empiric antibiotic and local thrombolytic therapy. Our patient's case underscores the importance of recognizing Fusobacterium bacteremia as a possible cause of suppurative PVT after disruption of the gastrointestinal mucosa following an acute intraabdominal infectious process. Early treatment of this condition using anticoagulation and endovascular thrombolysis as adjunctive therapies may prevent PVT complications. Elsevier 2015-07-14 /pmc/articles/PMC4712199/ /pubmed/26793462 http://dx.doi.org/10.1016/j.idcr.2015.07.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Akhrass, Fadi Al
Abdallah, Lina
Berger, Steven
Sartawi, Rami
Gastrointestinal variant of Lemierre's syndrome complicating ruptured appendicitis
title Gastrointestinal variant of Lemierre's syndrome complicating ruptured appendicitis
title_full Gastrointestinal variant of Lemierre's syndrome complicating ruptured appendicitis
title_fullStr Gastrointestinal variant of Lemierre's syndrome complicating ruptured appendicitis
title_full_unstemmed Gastrointestinal variant of Lemierre's syndrome complicating ruptured appendicitis
title_short Gastrointestinal variant of Lemierre's syndrome complicating ruptured appendicitis
title_sort gastrointestinal variant of lemierre's syndrome complicating ruptured appendicitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712199/
https://www.ncbi.nlm.nih.gov/pubmed/26793462
http://dx.doi.org/10.1016/j.idcr.2015.07.001
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