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A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged

We tested antibody responses to the trivalent inactivated influenza vaccine (TIV) in 34 aged individuals (>65yrs) during the 2012/13 vaccination seasons. Nearly all had been vaccinated the previous year although the time interval between the two vaccine doses differed. One subgroup was re-vaccina...

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Autores principales: Kannan, Senthil, Kossenkov, Andrew, Kurupati, Raj K., Xiang, Jason ZQ, Doyle, Susan A., Schmader, Kenneth E., Schowe, Louise, Ertl, Hildegund C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712333/
https://www.ncbi.nlm.nih.gov/pubmed/26637961
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author Kannan, Senthil
Kossenkov, Andrew
Kurupati, Raj K.
Xiang, Jason ZQ
Doyle, Susan A.
Schmader, Kenneth E.
Schowe, Louise
Ertl, Hildegund C.
author_facet Kannan, Senthil
Kossenkov, Andrew
Kurupati, Raj K.
Xiang, Jason ZQ
Doyle, Susan A.
Schmader, Kenneth E.
Schowe, Louise
Ertl, Hildegund C.
author_sort Kannan, Senthil
collection PubMed
description We tested antibody responses to the trivalent inactivated influenza vaccine (TIV) in 34 aged individuals (>65yrs) during the 2012/13 vaccination seasons. Nearly all had been vaccinated the previous year although the time interval between the two vaccine doses differed. One subgroup was re-vaccinated in 2012/13 within 6-9 months of their 2011/12 vaccination, the other received the two doses of vaccine in the typical ~12 month interval. Unexpectedly the sub-cohort with early revaccination exhibited significantly increased response rates and antibody titers to TIV compared to their normally re-vaccinated aged counter parts. Microarray analyses of gene expression in whole blood RNA taken at the day of the 2012/13 re-vaccination revealed statistically significant differences in expression of 754 genes between the individuals with early re-vaccination compared to subjects vaccinated in a normal 12 month interval. These observations suggest that TIV has long-lasting effects on the immune system affecting B cell responses as well as the transcriptome of peripheral blood mononuclear cells and this residual effect may augment vaccination response in patients where the effect of the previous vaccination has not yet diminished.
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spelling pubmed-47123332016-01-25 A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged Kannan, Senthil Kossenkov, Andrew Kurupati, Raj K. Xiang, Jason ZQ Doyle, Susan A. Schmader, Kenneth E. Schowe, Louise Ertl, Hildegund C. Aging (Albany NY) Research Paper We tested antibody responses to the trivalent inactivated influenza vaccine (TIV) in 34 aged individuals (>65yrs) during the 2012/13 vaccination seasons. Nearly all had been vaccinated the previous year although the time interval between the two vaccine doses differed. One subgroup was re-vaccinated in 2012/13 within 6-9 months of their 2011/12 vaccination, the other received the two doses of vaccine in the typical ~12 month interval. Unexpectedly the sub-cohort with early revaccination exhibited significantly increased response rates and antibody titers to TIV compared to their normally re-vaccinated aged counter parts. Microarray analyses of gene expression in whole blood RNA taken at the day of the 2012/13 re-vaccination revealed statistically significant differences in expression of 754 genes between the individuals with early re-vaccination compared to subjects vaccinated in a normal 12 month interval. These observations suggest that TIV has long-lasting effects on the immune system affecting B cell responses as well as the transcriptome of peripheral blood mononuclear cells and this residual effect may augment vaccination response in patients where the effect of the previous vaccination has not yet diminished. Impact Journals LLC 2015-12-03 /pmc/articles/PMC4712333/ /pubmed/26637961 Text en Copyright: © 2015 Kannan et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Kannan, Senthil
Kossenkov, Andrew
Kurupati, Raj K.
Xiang, Jason ZQ
Doyle, Susan A.
Schmader, Kenneth E.
Schowe, Louise
Ertl, Hildegund C.
A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged
title A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged
title_full A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged
title_fullStr A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged
title_full_unstemmed A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged
title_short A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged
title_sort shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712333/
https://www.ncbi.nlm.nih.gov/pubmed/26637961
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