NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation

A rise in the levels of the cyclin-dependent kinase (CDK) inhibitor p27(KIP1) is important for the growth arrest of senescent cells, but the mechanisms responsible for this increase are poorly understood. Here, we show that the tRNA methyltransferase NSun2 represses the expression of p27 in replicat...

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Detalles Bibliográficos
Autores principales: Tang, Hao, Fan, Xiuqin, Xing, Junyue, Liu, Zhenyun, Jiang, Bin, Dou, Yali, Gorospe, Myriam, Wang, Wengong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712338/
https://www.ncbi.nlm.nih.gov/pubmed/26687548

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