Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection

BACKGROUND: Early HIV-1 infection is characterized by high levels of HIV-1 replication and substantial CD4 T cell depletion in the intestinal mucosa, intestinal epithelial barrier breakdown, and microbial translocation. HIV-1-induced disruption of intestinal homeostasis has also been associated with...

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Detalles Bibliográficos
Autores principales: Dillon, Stephanie M., Lee, Eric J., Donovan, Andrew M., Guo, Kejun, Harper, Michael S., Frank, Daniel N., McCarter, Martin D., Santiago, Mario L., Wilson, Cara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712466/
https://www.ncbi.nlm.nih.gov/pubmed/26762145
http://dx.doi.org/10.1186/s12977-016-0237-1

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