The leukemogenic fusion gene MLL-AF9 alters microRNA expression pattern and inhibits monoblastic differentiation via miR-511 repression

BACKGROUND: In this study we explored the role of microRNAs (miRNAs) as mediators of leukemogenic effects of the fusion gene MLL-AF9, which results from a frequent chromosomal translocation in infant and monoblastic acute myeloid leukemia (AML). METHODS: We performed a specific and efficient knockdo...

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Detalles Bibliográficos
Autores principales: Fleischmann, Katrin K., Pagel, Philipp, von Frowein, Julia, Magg, Thomas, Roscher, Adelbert A., Schmid, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712549/
https://www.ncbi.nlm.nih.gov/pubmed/26762252
http://dx.doi.org/10.1186/s13046-016-0283-5

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