Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family

BACKGROUND: Dysfunctions in the PI3K/mTOR pathway have gained a lot of attention in autism research. This was initially based on the discovery of several monogenic autism spectrum disorders with mutations or defects in PI3K/mTOR signaling components. Recent genetic studies corroborate that defective...

Descripción completa

Detalles Bibliográficos
Autores principales: Poopal, Ashwini C., Schroeder, Lindsay M., Horn, Paul S., Bassell, Gary J., Gross, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712554/
https://www.ncbi.nlm.nih.gov/pubmed/26770665
http://dx.doi.org/10.1186/s13229-015-0066-4

Ejemplares similares

Ejemplares similares