Expanding the diversity of DNA base modifications with N(6)-methyldeoxyadenosine

Vertebrate DNA is subjected to epigenetic base modifications that have been thought to be limited to methylated and other modified forms of cytidine. A recent study shows that methylation of adenine to form N(6)-methyladenine is a rare but readily detectable modification that can be mapped to distin...

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Detalles Bibliográficos
Autores principales: Meyer, Kate D., Jaffrey, Samie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712593/
https://www.ncbi.nlm.nih.gov/pubmed/26762117
http://dx.doi.org/10.1186/s13059-016-0874-7
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author Meyer, Kate D.
Jaffrey, Samie R.
author_facet Meyer, Kate D.
Jaffrey, Samie R.
author_sort Meyer, Kate D.
collection PubMed
description Vertebrate DNA is subjected to epigenetic base modifications that have been thought to be limited to methylated and other modified forms of cytidine. A recent study shows that methylation of adenine to form N(6)-methyladenine is a rare but readily detectable modification that can be mapped to distinct genomic sites in vertebrates.
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spelling pubmed-47125932016-01-15 Expanding the diversity of DNA base modifications with N(6)-methyldeoxyadenosine Meyer, Kate D. Jaffrey, Samie R. Genome Biol Research Highlight Vertebrate DNA is subjected to epigenetic base modifications that have been thought to be limited to methylated and other modified forms of cytidine. A recent study shows that methylation of adenine to form N(6)-methyladenine is a rare but readily detectable modification that can be mapped to distinct genomic sites in vertebrates. BioMed Central 2016-01-13 2016 /pmc/articles/PMC4712593/ /pubmed/26762117 http://dx.doi.org/10.1186/s13059-016-0874-7 Text en © Meyer and Jaffrey. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Meyer, Kate D.
Jaffrey, Samie R.
Expanding the diversity of DNA base modifications with N(6)-methyldeoxyadenosine
title Expanding the diversity of DNA base modifications with N(6)-methyldeoxyadenosine
title_full Expanding the diversity of DNA base modifications with N(6)-methyldeoxyadenosine
title_fullStr Expanding the diversity of DNA base modifications with N(6)-methyldeoxyadenosine
title_full_unstemmed Expanding the diversity of DNA base modifications with N(6)-methyldeoxyadenosine
title_short Expanding the diversity of DNA base modifications with N(6)-methyldeoxyadenosine
title_sort expanding the diversity of dna base modifications with n(6)-methyldeoxyadenosine
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712593/
https://www.ncbi.nlm.nih.gov/pubmed/26762117
http://dx.doi.org/10.1186/s13059-016-0874-7
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