Cracking the epitranscriptome

Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification...

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Detalles Bibliográficos
Autor principal: Schwartz, Schraga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712667/
https://www.ncbi.nlm.nih.gov/pubmed/26787305
http://dx.doi.org/10.1261/rna.054502.115
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author Schwartz, Schraga
author_facet Schwartz, Schraga
author_sort Schwartz, Schraga
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description Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made in recent years. The discussed aspects are also very relevant for a wide range of additional modifications on mRNA collectively coined the epitranscriptome.
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spelling pubmed-47126672017-02-01 Cracking the epitranscriptome Schwartz, Schraga RNA Mini-Review Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made in recent years. The discussed aspects are also very relevant for a wide range of additional modifications on mRNA collectively coined the epitranscriptome. Cold Spring Harbor Laboratory Press 2016-02 /pmc/articles/PMC4712667/ /pubmed/26787305 http://dx.doi.org/10.1261/rna.054502.115 Text en © 2016 Schwartz; Published by Cold Spring Harbor Laboratory Press for the RNA Society http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Mini-Review
Schwartz, Schraga
Cracking the epitranscriptome
title Cracking the epitranscriptome
title_full Cracking the epitranscriptome
title_fullStr Cracking the epitranscriptome
title_full_unstemmed Cracking the epitranscriptome
title_short Cracking the epitranscriptome
title_sort cracking the epitranscriptome
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712667/
https://www.ncbi.nlm.nih.gov/pubmed/26787305
http://dx.doi.org/10.1261/rna.054502.115
work_keys_str_mv AT schwartzschraga crackingtheepitranscriptome

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