A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting

During microRNA (miRNA) biogenesis, the Microprocessor complex (MC), composed minimally of Drosha, an RNaseIII enzyme, and DGCR8, a double-stranded RNA-binding protein, cleaves the primary-miRNA (pri-miRNA) to release the pre-miRNA stem–loop structure. Size-exclusion chromatography of the MC, isolat...

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Detalles Bibliográficos
Autores principales: Herbert, Kristina M., Sarkar, Susanta K., Mills, Maria, Delgado De la Herran, Hilda C., Neuman, Keir C., Steitz, Joan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712668/
https://www.ncbi.nlm.nih.gov/pubmed/26683315
http://dx.doi.org/10.1261/rna.054684.115

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