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Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma
Reprogrammed glucose metabolism is an emerging hallmark of cancer cells, which show a unique metabolic phenotype known as the Warburg effect. Lactate dehydrogenase A (LDHA), a key enzyme in the glycolytic process, executes the final step by conversion of lactate into pyruvate. However, little is kno...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Lippincott Williams & Wilkins
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712768/ https://www.ncbi.nlm.nih.gov/pubmed/26694942 http://dx.doi.org/10.1097/WNR.0000000000000506 |