Cargando…

Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy

Lack of physical engagement, productivity, and initiative—so-called “behavioral apathy”—is a common problem with significant impact, both personal and economic. Here, we investigate whether there might be a biological basis to such lack of motivation using a new effort and reward-based decision-maki...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonnelle, Valerie, Manohar, Sanjay, Behrens, Tim, Husain, Masud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712805/
https://www.ncbi.nlm.nih.gov/pubmed/26564255
http://dx.doi.org/10.1093/cercor/bhv247
_version_ 1782410114794258432
author Bonnelle, Valerie
Manohar, Sanjay
Behrens, Tim
Husain, Masud
author_facet Bonnelle, Valerie
Manohar, Sanjay
Behrens, Tim
Husain, Masud
author_sort Bonnelle, Valerie
collection PubMed
description Lack of physical engagement, productivity, and initiative—so-called “behavioral apathy”—is a common problem with significant impact, both personal and economic. Here, we investigate whether there might be a biological basis to such lack of motivation using a new effort and reward-based decision-making paradigm, combined with functional and diffusion-weighted imaging. We hypothesized that behavioral apathy in otherwise healthy people might be associated with differences in brain systems underlying either motivation to act (specifically in effort and reward-based decision-making) or in action processing (transformation of an intention into action). The results demonstrate that behavioral apathy is associated with increased effort sensitivity as well as greater recruitment of neural systems involved in action anticipation: supplementary motor area (SMA) and cingulate motor zones. In addition, decreased structural and functional connectivity between anterior cingulate cortex (ACC) and SMA were associated with increased behavioral apathy. These findings reveal that effort sensitivity and translation of intentions into actions might make a critical contribution to behavioral apathy. We propose a mechanism whereby inefficient communication between ACC and SMA might lead to increased physiological cost—and greater effort sensitivity—for action initiation in more apathetic people.
format Online
Article
Text
id pubmed-4712805
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-47128052016-01-19 Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy Bonnelle, Valerie Manohar, Sanjay Behrens, Tim Husain, Masud Cereb Cortex Articles Lack of physical engagement, productivity, and initiative—so-called “behavioral apathy”—is a common problem with significant impact, both personal and economic. Here, we investigate whether there might be a biological basis to such lack of motivation using a new effort and reward-based decision-making paradigm, combined with functional and diffusion-weighted imaging. We hypothesized that behavioral apathy in otherwise healthy people might be associated with differences in brain systems underlying either motivation to act (specifically in effort and reward-based decision-making) or in action processing (transformation of an intention into action). The results demonstrate that behavioral apathy is associated with increased effort sensitivity as well as greater recruitment of neural systems involved in action anticipation: supplementary motor area (SMA) and cingulate motor zones. In addition, decreased structural and functional connectivity between anterior cingulate cortex (ACC) and SMA were associated with increased behavioral apathy. These findings reveal that effort sensitivity and translation of intentions into actions might make a critical contribution to behavioral apathy. We propose a mechanism whereby inefficient communication between ACC and SMA might lead to increased physiological cost—and greater effort sensitivity—for action initiation in more apathetic people. Oxford University Press 2016-02 2015-11-12 /pmc/articles/PMC4712805/ /pubmed/26564255 http://dx.doi.org/10.1093/cercor/bhv247 Text en © The Author 2015. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Bonnelle, Valerie
Manohar, Sanjay
Behrens, Tim
Husain, Masud
Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy
title Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy
title_full Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy
title_fullStr Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy
title_full_unstemmed Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy
title_short Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy
title_sort individual differences in premotor brain systems underlie behavioral apathy
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712805/
https://www.ncbi.nlm.nih.gov/pubmed/26564255
http://dx.doi.org/10.1093/cercor/bhv247
work_keys_str_mv AT bonnellevalerie individualdifferencesinpremotorbrainsystemsunderliebehavioralapathy
AT manoharsanjay individualdifferencesinpremotorbrainsystemsunderliebehavioralapathy
AT behrenstim individualdifferencesinpremotorbrainsystemsunderliebehavioralapathy
AT husainmasud individualdifferencesinpremotorbrainsystemsunderliebehavioralapathy