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Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy
Lack of physical engagement, productivity, and initiative—so-called “behavioral apathy”—is a common problem with significant impact, both personal and economic. Here, we investigate whether there might be a biological basis to such lack of motivation using a new effort and reward-based decision-maki...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712805/ https://www.ncbi.nlm.nih.gov/pubmed/26564255 http://dx.doi.org/10.1093/cercor/bhv247 |
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author | Bonnelle, Valerie Manohar, Sanjay Behrens, Tim Husain, Masud |
author_facet | Bonnelle, Valerie Manohar, Sanjay Behrens, Tim Husain, Masud |
author_sort | Bonnelle, Valerie |
collection | PubMed |
description | Lack of physical engagement, productivity, and initiative—so-called “behavioral apathy”—is a common problem with significant impact, both personal and economic. Here, we investigate whether there might be a biological basis to such lack of motivation using a new effort and reward-based decision-making paradigm, combined with functional and diffusion-weighted imaging. We hypothesized that behavioral apathy in otherwise healthy people might be associated with differences in brain systems underlying either motivation to act (specifically in effort and reward-based decision-making) or in action processing (transformation of an intention into action). The results demonstrate that behavioral apathy is associated with increased effort sensitivity as well as greater recruitment of neural systems involved in action anticipation: supplementary motor area (SMA) and cingulate motor zones. In addition, decreased structural and functional connectivity between anterior cingulate cortex (ACC) and SMA were associated with increased behavioral apathy. These findings reveal that effort sensitivity and translation of intentions into actions might make a critical contribution to behavioral apathy. We propose a mechanism whereby inefficient communication between ACC and SMA might lead to increased physiological cost—and greater effort sensitivity—for action initiation in more apathetic people. |
format | Online Article Text |
id | pubmed-4712805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47128052016-01-19 Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy Bonnelle, Valerie Manohar, Sanjay Behrens, Tim Husain, Masud Cereb Cortex Articles Lack of physical engagement, productivity, and initiative—so-called “behavioral apathy”—is a common problem with significant impact, both personal and economic. Here, we investigate whether there might be a biological basis to such lack of motivation using a new effort and reward-based decision-making paradigm, combined with functional and diffusion-weighted imaging. We hypothesized that behavioral apathy in otherwise healthy people might be associated with differences in brain systems underlying either motivation to act (specifically in effort and reward-based decision-making) or in action processing (transformation of an intention into action). The results demonstrate that behavioral apathy is associated with increased effort sensitivity as well as greater recruitment of neural systems involved in action anticipation: supplementary motor area (SMA) and cingulate motor zones. In addition, decreased structural and functional connectivity between anterior cingulate cortex (ACC) and SMA were associated with increased behavioral apathy. These findings reveal that effort sensitivity and translation of intentions into actions might make a critical contribution to behavioral apathy. We propose a mechanism whereby inefficient communication between ACC and SMA might lead to increased physiological cost—and greater effort sensitivity—for action initiation in more apathetic people. Oxford University Press 2016-02 2015-11-12 /pmc/articles/PMC4712805/ /pubmed/26564255 http://dx.doi.org/10.1093/cercor/bhv247 Text en © The Author 2015. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Bonnelle, Valerie Manohar, Sanjay Behrens, Tim Husain, Masud Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy |
title | Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy |
title_full | Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy |
title_fullStr | Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy |
title_full_unstemmed | Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy |
title_short | Individual Differences in Premotor Brain Systems Underlie Behavioral Apathy |
title_sort | individual differences in premotor brain systems underlie behavioral apathy |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712805/ https://www.ncbi.nlm.nih.gov/pubmed/26564255 http://dx.doi.org/10.1093/cercor/bhv247 |
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