Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites

Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging method and Oxygen Radical Absorbance Capacity (...

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Autores principales: Choudhury, Ambar K., Raja, Suganya, Mahapatra, Sanjata, Nagabhushanam, Kalyanam, Majeed, Muhammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712937/
https://www.ncbi.nlm.nih.gov/pubmed/26783957
http://dx.doi.org/10.3390/antiox4040750
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author Choudhury, Ambar K.
Raja, Suganya
Mahapatra, Sanjata
Nagabhushanam, Kalyanam
Majeed, Muhammed
author_facet Choudhury, Ambar K.
Raja, Suganya
Mahapatra, Sanjata
Nagabhushanam, Kalyanam
Majeed, Muhammed
author_sort Choudhury, Ambar K.
collection PubMed
description Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging method and Oxygen Radical Absorbance Capacity (ORAC) assay. The results show that curcumin monoglucuronide exhibits 10 fold less anti-oxidant activity (DPPH method) and the anti-oxidant capacity of curcumin diglucuronide is highly attenuated compared to the anti-oxidant activity of curcumin.
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spelling pubmed-47129372016-01-14 Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites Choudhury, Ambar K. Raja, Suganya Mahapatra, Sanjata Nagabhushanam, Kalyanam Majeed, Muhammed Antioxidants (Basel) Article Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging method and Oxygen Radical Absorbance Capacity (ORAC) assay. The results show that curcumin monoglucuronide exhibits 10 fold less anti-oxidant activity (DPPH method) and the anti-oxidant capacity of curcumin diglucuronide is highly attenuated compared to the anti-oxidant activity of curcumin. MDPI 2015-12-02 /pmc/articles/PMC4712937/ /pubmed/26783957 http://dx.doi.org/10.3390/antiox4040750 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choudhury, Ambar K.
Raja, Suganya
Mahapatra, Sanjata
Nagabhushanam, Kalyanam
Majeed, Muhammed
Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites
title Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites
title_full Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites
title_fullStr Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites
title_full_unstemmed Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites
title_short Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites
title_sort synthesis and evaluation of the anti-oxidant capacity of curcumin glucuronides, the major curcumin metabolites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712937/
https://www.ncbi.nlm.nih.gov/pubmed/26783957
http://dx.doi.org/10.3390/antiox4040750
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