Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants

Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of...

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Detalles Bibliográficos
Autores principales: Odone, Anna, Calderon, Roger, Becerra, Mercedes C., Zhang, Zibiao, Contreras, Carmen C., Yataco, Rosa, Galea, Jerome, Lecca, Leonid, Bonds, Matthew H., Mitnick, Carole D., Murray, Megan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713093/
https://www.ncbi.nlm.nih.gov/pubmed/26765328
http://dx.doi.org/10.1371/journal.pone.0146642
Descripción
Sumario:Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of index TB patients and their household contacts in Lima, Peru to identify risk factors associated with acquired and transmitted resistance, respectively. Patients with higher socioeconomic status (SES) had a 3-fold increased risk of transmitted resistance compared to those with lower SES when acquired resistance served as the baseline. Quality of housing mediated most of the impact of SES.

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