Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants

Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of...

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Autores principales: Odone, Anna, Calderon, Roger, Becerra, Mercedes C., Zhang, Zibiao, Contreras, Carmen C., Yataco, Rosa, Galea, Jerome, Lecca, Leonid, Bonds, Matthew H., Mitnick, Carole D., Murray, Megan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713093/
https://www.ncbi.nlm.nih.gov/pubmed/26765328
http://dx.doi.org/10.1371/journal.pone.0146642
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author Odone, Anna
Calderon, Roger
Becerra, Mercedes C.
Zhang, Zibiao
Contreras, Carmen C.
Yataco, Rosa
Galea, Jerome
Lecca, Leonid
Bonds, Matthew H.
Mitnick, Carole D.
Murray, Megan B.
author_facet Odone, Anna
Calderon, Roger
Becerra, Mercedes C.
Zhang, Zibiao
Contreras, Carmen C.
Yataco, Rosa
Galea, Jerome
Lecca, Leonid
Bonds, Matthew H.
Mitnick, Carole D.
Murray, Megan B.
author_sort Odone, Anna
collection PubMed
description Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of index TB patients and their household contacts in Lima, Peru to identify risk factors associated with acquired and transmitted resistance, respectively. Patients with higher socioeconomic status (SES) had a 3-fold increased risk of transmitted resistance compared to those with lower SES when acquired resistance served as the baseline. Quality of housing mediated most of the impact of SES.
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spelling pubmed-47130932016-01-26 Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants Odone, Anna Calderon, Roger Becerra, Mercedes C. Zhang, Zibiao Contreras, Carmen C. Yataco, Rosa Galea, Jerome Lecca, Leonid Bonds, Matthew H. Mitnick, Carole D. Murray, Megan B. PLoS One Research Article Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of index TB patients and their household contacts in Lima, Peru to identify risk factors associated with acquired and transmitted resistance, respectively. Patients with higher socioeconomic status (SES) had a 3-fold increased risk of transmitted resistance compared to those with lower SES when acquired resistance served as the baseline. Quality of housing mediated most of the impact of SES. Public Library of Science 2016-01-14 /pmc/articles/PMC4713093/ /pubmed/26765328 http://dx.doi.org/10.1371/journal.pone.0146642 Text en © 2016 Odone et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Odone, Anna
Calderon, Roger
Becerra, Mercedes C.
Zhang, Zibiao
Contreras, Carmen C.
Yataco, Rosa
Galea, Jerome
Lecca, Leonid
Bonds, Matthew H.
Mitnick, Carole D.
Murray, Megan B.
Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants
title Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants
title_full Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants
title_fullStr Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants
title_full_unstemmed Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants
title_short Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants
title_sort acquired and transmitted multidrug resistant tuberculosis: the role of social determinants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713093/
https://www.ncbi.nlm.nih.gov/pubmed/26765328
http://dx.doi.org/10.1371/journal.pone.0146642
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