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Dual Endothelin Receptor Blockade Abrogates Right Ventricular Remodeling and Biventricular Fibrosis in Isolated Elevated Right Ventricular Afterload

BACKGROUND: Pulmonary arterial hypertension is usually fatal due to right ventricular failure and is frequently associated with co-existing left ventricular dysfunction. Endothelin-1 is a powerful pro-fibrotic mediator and vasoconstrictor that is elevated in pulmonary arterial hypertension. Endothel...

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Detalles Bibliográficos
Autores principales:	Nielsen, Eva Amalie, Sun, Mei, Honjo, Osami, Hjortdal, Vibeke E., Redington, Andrew N., Friedberg, Mark K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713098/ https://www.ncbi.nlm.nih.gov/pubmed/26765263 http://dx.doi.org/10.1371/journal.pone.0146767

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