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Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

Mitochondrial DNA (mtDNA) deletions are associated with various mitochondrial disorders. The deletions identified in humans are flanked by short, directly repeated mitochondrial DNA sequences; however, the mechanism of such DNA rearrangements has yet to be elucidated. In contrast to nuclear DNA (nDN...

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Detalles Bibliográficos
Autores principales:	Tadi, Satish Kumar, Sebastian, Robin, Dahal, Sumedha, Babu, Ravi K., Choudhary, Bibha, Raghavan, Sathees C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713127/ https://www.ncbi.nlm.nih.gov/pubmed/26609070 http://dx.doi.org/10.1091/mbc.E15-05-0260

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