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Locus-specific gene repositioning in prostate cancer
Genes occupy preferred spatial positions within interphase cell nuclei. However, positioning patterns are not an innate feature of a locus, and genes can alter their localization in response to physiological and pathological changes. Here we screen the radial positioning patterns of 40 genes in norm...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713128/ https://www.ncbi.nlm.nih.gov/pubmed/26564800 http://dx.doi.org/10.1091/mbc.E15-05-0280 |
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author | Leshner, Marc Devine, Michelle Roloff, Gregory W. True, Lawrence D. Misteli, Tom Meaburn, Karen J. |
author_facet | Leshner, Marc Devine, Michelle Roloff, Gregory W. True, Lawrence D. Misteli, Tom Meaburn, Karen J. |
author_sort | Leshner, Marc |
collection | PubMed |
description | Genes occupy preferred spatial positions within interphase cell nuclei. However, positioning patterns are not an innate feature of a locus, and genes can alter their localization in response to physiological and pathological changes. Here we screen the radial positioning patterns of 40 genes in normal, hyperplasic, and malignant human prostate tissues. We find that the overall spatial organization of the genome in prostate tissue is largely conserved among individuals. We identify three genes whose nuclear positions are robustly altered in neoplastic prostate tissues. FLI1 and MMP9 position differently in prostate cancer than in normal tissue and prostate hyperplasia, whereas MMP2 is repositioned in both prostate cancer and hyperplasia. Our data point to locus-specific reorganization of the genome during prostate disease. |
format | Online Article Text |
id | pubmed-4713128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-47131282016-03-30 Locus-specific gene repositioning in prostate cancer Leshner, Marc Devine, Michelle Roloff, Gregory W. True, Lawrence D. Misteli, Tom Meaburn, Karen J. Mol Biol Cell Articles Genes occupy preferred spatial positions within interphase cell nuclei. However, positioning patterns are not an innate feature of a locus, and genes can alter their localization in response to physiological and pathological changes. Here we screen the radial positioning patterns of 40 genes in normal, hyperplasic, and malignant human prostate tissues. We find that the overall spatial organization of the genome in prostate tissue is largely conserved among individuals. We identify three genes whose nuclear positions are robustly altered in neoplastic prostate tissues. FLI1 and MMP9 position differently in prostate cancer than in normal tissue and prostate hyperplasia, whereas MMP2 is repositioned in both prostate cancer and hyperplasia. Our data point to locus-specific reorganization of the genome during prostate disease. The American Society for Cell Biology 2016-01-15 /pmc/articles/PMC4713128/ /pubmed/26564800 http://dx.doi.org/10.1091/mbc.E15-05-0280 Text en © 2016 Leshner et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. |
spellingShingle | Articles Leshner, Marc Devine, Michelle Roloff, Gregory W. True, Lawrence D. Misteli, Tom Meaburn, Karen J. Locus-specific gene repositioning in prostate cancer |
title | Locus-specific gene repositioning in prostate cancer |
title_full | Locus-specific gene repositioning in prostate cancer |
title_fullStr | Locus-specific gene repositioning in prostate cancer |
title_full_unstemmed | Locus-specific gene repositioning in prostate cancer |
title_short | Locus-specific gene repositioning in prostate cancer |
title_sort | locus-specific gene repositioning in prostate cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713128/ https://www.ncbi.nlm.nih.gov/pubmed/26564800 http://dx.doi.org/10.1091/mbc.E15-05-0280 |
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