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WNT-5A: signaling and functions in health and disease
WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can als...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713724/ https://www.ncbi.nlm.nih.gov/pubmed/26514730 http://dx.doi.org/10.1007/s00018-015-2076-y |
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author | Kumawat, Kuldeep Gosens, Reinoud |
author_facet | Kumawat, Kuldeep Gosens, Reinoud |
author_sort | Kumawat, Kuldeep |
collection | PubMed |
description | WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation. Moreover, aberrant WNT-5A signaling is associated with several human pathologies such as cancer, fibrosis, and inflammation. Thus, owing to its diverse functions, WNT-5A is a crucial signaling molecule currently under intense investigation with efforts to not only delineate its signaling mechanisms and functions in physiological and pathological conditions, but also to develop strategies for its therapeutic targeting. |
format | Online Article Text |
id | pubmed-4713724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-47137242016-01-21 WNT-5A: signaling and functions in health and disease Kumawat, Kuldeep Gosens, Reinoud Cell Mol Life Sci Review WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation. Moreover, aberrant WNT-5A signaling is associated with several human pathologies such as cancer, fibrosis, and inflammation. Thus, owing to its diverse functions, WNT-5A is a crucial signaling molecule currently under intense investigation with efforts to not only delineate its signaling mechanisms and functions in physiological and pathological conditions, but also to develop strategies for its therapeutic targeting. Springer International Publishing 2015-10-29 2016 /pmc/articles/PMC4713724/ /pubmed/26514730 http://dx.doi.org/10.1007/s00018-015-2076-y Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Kumawat, Kuldeep Gosens, Reinoud WNT-5A: signaling and functions in health and disease |
title | WNT-5A: signaling and functions in health and disease |
title_full | WNT-5A: signaling and functions in health and disease |
title_fullStr | WNT-5A: signaling and functions in health and disease |
title_full_unstemmed | WNT-5A: signaling and functions in health and disease |
title_short | WNT-5A: signaling and functions in health and disease |
title_sort | wnt-5a: signaling and functions in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713724/ https://www.ncbi.nlm.nih.gov/pubmed/26514730 http://dx.doi.org/10.1007/s00018-015-2076-y |
work_keys_str_mv | AT kumawatkuldeep wnt5asignalingandfunctionsinhealthanddisease AT gosensreinoud wnt5asignalingandfunctionsinhealthanddisease |