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WNT-5A: signaling and functions in health and disease

WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can als...

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Detalles Bibliográficos
Autores principales: Kumawat, Kuldeep, Gosens, Reinoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713724/
https://www.ncbi.nlm.nih.gov/pubmed/26514730
http://dx.doi.org/10.1007/s00018-015-2076-y
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author Kumawat, Kuldeep
Gosens, Reinoud
author_facet Kumawat, Kuldeep
Gosens, Reinoud
author_sort Kumawat, Kuldeep
collection PubMed
description WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation. Moreover, aberrant WNT-5A signaling is associated with several human pathologies such as cancer, fibrosis, and inflammation. Thus, owing to its diverse functions, WNT-5A is a crucial signaling molecule currently under intense investigation with efforts to not only delineate its signaling mechanisms and functions in physiological and pathological conditions, but also to develop strategies for its therapeutic targeting.
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spelling pubmed-47137242016-01-21 WNT-5A: signaling and functions in health and disease Kumawat, Kuldeep Gosens, Reinoud Cell Mol Life Sci Review WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation. Moreover, aberrant WNT-5A signaling is associated with several human pathologies such as cancer, fibrosis, and inflammation. Thus, owing to its diverse functions, WNT-5A is a crucial signaling molecule currently under intense investigation with efforts to not only delineate its signaling mechanisms and functions in physiological and pathological conditions, but also to develop strategies for its therapeutic targeting. Springer International Publishing 2015-10-29 2016 /pmc/articles/PMC4713724/ /pubmed/26514730 http://dx.doi.org/10.1007/s00018-015-2076-y Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Kumawat, Kuldeep
Gosens, Reinoud
WNT-5A: signaling and functions in health and disease
title WNT-5A: signaling and functions in health and disease
title_full WNT-5A: signaling and functions in health and disease
title_fullStr WNT-5A: signaling and functions in health and disease
title_full_unstemmed WNT-5A: signaling and functions in health and disease
title_short WNT-5A: signaling and functions in health and disease
title_sort wnt-5a: signaling and functions in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713724/
https://www.ncbi.nlm.nih.gov/pubmed/26514730
http://dx.doi.org/10.1007/s00018-015-2076-y
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