Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells

During retroviral infection, viral capsids are subject to restriction by the cellular factor TRIM5α. Here, we show that dendritic cells (DCs) derived from human and non-human primate species lack efficient TRIM5α-mediated retroviral restriction. In DCs, endogenous TRIM5α accumulates in nuclear bodie...

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Detalles Bibliográficos
Autores principales: Portilho, Débora M., Fernandez, Juliette, Ringeard, Mathieu, Machado, Anthony K., Boulay, Aude, Mayer, Martha, Müller-Trutwin, Michaela, Beignon, Anne-Sophie, Kirchhoff, Frank, Nisole, Sébastien, Arhel, Nathalie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713866/
https://www.ncbi.nlm.nih.gov/pubmed/26748714
http://dx.doi.org/10.1016/j.celrep.2015.12.039

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