The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor

Drug-induced anaphylaxis is a big pitfall in patients receiving antineoplastic chemotherapy. We report a case of lung cancer patient who experienced two near-fatal anaphylactic reactions that resulted from paclitaxel and multivitamin, seperately. Recurrent severe reactions to different agents led to...

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Autores principales: Kim, Young Nam, Kim, Jun Young, Kim, Ji Won, Kim, Jin Hae, Kim, Hye In, Yune, Sehyo, Choi, Dong-Chull, Lee, Byung-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713882/
https://www.ncbi.nlm.nih.gov/pubmed/26739412
http://dx.doi.org/10.4168/aair.2016.8.2.174
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author Kim, Young Nam
Kim, Jun Young
Kim, Ji Won
Kim, Jin Hae
Kim, Hye In
Yune, Sehyo
Choi, Dong-Chull
Lee, Byung-Jae
author_facet Kim, Young Nam
Kim, Jun Young
Kim, Ji Won
Kim, Jin Hae
Kim, Hye In
Yune, Sehyo
Choi, Dong-Chull
Lee, Byung-Jae
author_sort Kim, Young Nam
collection PubMed
description Drug-induced anaphylaxis is a big pitfall in patients receiving antineoplastic chemotherapy. We report a case of lung cancer patient who experienced two near-fatal anaphylactic reactions that resulted from paclitaxel and multivitamin, seperately. Recurrent severe reactions to different agents led to further investigation to which material the patient was hypersensitive. The skin prick test revealed sensitization to cremophor, which is a commonly used emulsifying agent. This case emphasizes the importance of correctly identifying the culprit drug of anaphylaxis to avoid potentially fatal reaction.
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spelling pubmed-47138822016-03-01 The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor Kim, Young Nam Kim, Jun Young Kim, Ji Won Kim, Jin Hae Kim, Hye In Yune, Sehyo Choi, Dong-Chull Lee, Byung-Jae Allergy Asthma Immunol Res Case Report Drug-induced anaphylaxis is a big pitfall in patients receiving antineoplastic chemotherapy. We report a case of lung cancer patient who experienced two near-fatal anaphylactic reactions that resulted from paclitaxel and multivitamin, seperately. Recurrent severe reactions to different agents led to further investigation to which material the patient was hypersensitive. The skin prick test revealed sensitization to cremophor, which is a commonly used emulsifying agent. This case emphasizes the importance of correctly identifying the culprit drug of anaphylaxis to avoid potentially fatal reaction. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2016-03 2015-11-10 /pmc/articles/PMC4713882/ /pubmed/26739412 http://dx.doi.org/10.4168/aair.2016.8.2.174 Text en Copyright © 2016 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kim, Young Nam
Kim, Jun Young
Kim, Ji Won
Kim, Jin Hae
Kim, Hye In
Yune, Sehyo
Choi, Dong-Chull
Lee, Byung-Jae
The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor
title The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor
title_full The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor
title_fullStr The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor
title_full_unstemmed The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor
title_short The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor
title_sort hidden culprit: a case of repeated anaphylaxis to cremophor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713882/
https://www.ncbi.nlm.nih.gov/pubmed/26739412
http://dx.doi.org/10.4168/aair.2016.8.2.174
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