Cargando…
Immunologic monitoring in kidney transplant recipients
Transplant biopsy has always been the gold standard for assessing the immune response to a kidney allograft (Chandraker A: Diagnostic techniques in the work-up of renal allograft dysfunction—an update. Curr Opin Nephrol Hypertens 8:723–728, 1999). A biopsy is not without risk and is unable to predic...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713911/ https://www.ncbi.nlm.nih.gov/pubmed/26877913 http://dx.doi.org/10.1016/j.krcp.2013.04.002 |
_version_ | 1782410221843382272 |
---|---|
author | Townamchai, Natavudh Safa, Kassem Chandraker, Anil |
author_facet | Townamchai, Natavudh Safa, Kassem Chandraker, Anil |
author_sort | Townamchai, Natavudh |
collection | PubMed |
description | Transplant biopsy has always been the gold standard for assessing the immune response to a kidney allograft (Chandraker A: Diagnostic techniques in the work-up of renal allograft dysfunction—an update. Curr Opin Nephrol Hypertens 8:723–728, 1999). A biopsy is not without risk and is unable to predict rejection and is only diagnostic once rejection has already occurred. However, in the past two decades, we have seen an expansion in assays that can potentially put an end to the “drug level” era, which until now has been one of the few tools available to clinicians for monitoring the immune response. A better understanding of the mechanisms of rejection and tolerance, and technological advances has led to the development of new noninvasive methods to monitor the immune response. In this article, we discuss these new methods and their potential uses in renal transplant recipients. |
format | Online Article Text |
id | pubmed-4713911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-47139112016-02-12 Immunologic monitoring in kidney transplant recipients Townamchai, Natavudh Safa, Kassem Chandraker, Anil Kidney Res Clin Pract Review Article Transplant biopsy has always been the gold standard for assessing the immune response to a kidney allograft (Chandraker A: Diagnostic techniques in the work-up of renal allograft dysfunction—an update. Curr Opin Nephrol Hypertens 8:723–728, 1999). A biopsy is not without risk and is unable to predict rejection and is only diagnostic once rejection has already occurred. However, in the past two decades, we have seen an expansion in assays that can potentially put an end to the “drug level” era, which until now has been one of the few tools available to clinicians for monitoring the immune response. A better understanding of the mechanisms of rejection and tolerance, and technological advances has led to the development of new noninvasive methods to monitor the immune response. In this article, we discuss these new methods and their potential uses in renal transplant recipients. Elsevier 2013-06 2013-05-29 /pmc/articles/PMC4713911/ /pubmed/26877913 http://dx.doi.org/10.1016/j.krcp.2013.04.002 Text en © 2013. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Townamchai, Natavudh Safa, Kassem Chandraker, Anil Immunologic monitoring in kidney transplant recipients |
title | Immunologic monitoring in kidney transplant recipients |
title_full | Immunologic monitoring in kidney transplant recipients |
title_fullStr | Immunologic monitoring in kidney transplant recipients |
title_full_unstemmed | Immunologic monitoring in kidney transplant recipients |
title_short | Immunologic monitoring in kidney transplant recipients |
title_sort | immunologic monitoring in kidney transplant recipients |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713911/ https://www.ncbi.nlm.nih.gov/pubmed/26877913 http://dx.doi.org/10.1016/j.krcp.2013.04.002 |
work_keys_str_mv | AT townamchainatavudh immunologicmonitoringinkidneytransplantrecipients AT safakassem immunologicmonitoringinkidneytransplantrecipients AT chandrakeranil immunologicmonitoringinkidneytransplantrecipients |