Cargando…

Immunologic monitoring in kidney transplant recipients

Transplant biopsy has always been the gold standard for assessing the immune response to a kidney allograft (Chandraker A: Diagnostic techniques in the work-up of renal allograft dysfunction—an update. Curr Opin Nephrol Hypertens 8:723–728, 1999). A biopsy is not without risk and is unable to predic...

Descripción completa

Detalles Bibliográficos
Autores principales: Townamchai, Natavudh, Safa, Kassem, Chandraker, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713911/
https://www.ncbi.nlm.nih.gov/pubmed/26877913
http://dx.doi.org/10.1016/j.krcp.2013.04.002
_version_ 1782410221843382272
author Townamchai, Natavudh
Safa, Kassem
Chandraker, Anil
author_facet Townamchai, Natavudh
Safa, Kassem
Chandraker, Anil
author_sort Townamchai, Natavudh
collection PubMed
description Transplant biopsy has always been the gold standard for assessing the immune response to a kidney allograft (Chandraker A: Diagnostic techniques in the work-up of renal allograft dysfunction—an update. Curr Opin Nephrol Hypertens 8:723–728, 1999). A biopsy is not without risk and is unable to predict rejection and is only diagnostic once rejection has already occurred. However, in the past two decades, we have seen an expansion in assays that can potentially put an end to the “drug level” era, which until now has been one of the few tools available to clinicians for monitoring the immune response. A better understanding of the mechanisms of rejection and tolerance, and technological advances has led to the development of new noninvasive methods to monitor the immune response. In this article, we discuss these new methods and their potential uses in renal transplant recipients.
format Online
Article
Text
id pubmed-4713911
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-47139112016-02-12 Immunologic monitoring in kidney transplant recipients Townamchai, Natavudh Safa, Kassem Chandraker, Anil Kidney Res Clin Pract Review Article Transplant biopsy has always been the gold standard for assessing the immune response to a kidney allograft (Chandraker A: Diagnostic techniques in the work-up of renal allograft dysfunction—an update. Curr Opin Nephrol Hypertens 8:723–728, 1999). A biopsy is not without risk and is unable to predict rejection and is only diagnostic once rejection has already occurred. However, in the past two decades, we have seen an expansion in assays that can potentially put an end to the “drug level” era, which until now has been one of the few tools available to clinicians for monitoring the immune response. A better understanding of the mechanisms of rejection and tolerance, and technological advances has led to the development of new noninvasive methods to monitor the immune response. In this article, we discuss these new methods and their potential uses in renal transplant recipients. Elsevier 2013-06 2013-05-29 /pmc/articles/PMC4713911/ /pubmed/26877913 http://dx.doi.org/10.1016/j.krcp.2013.04.002 Text en © 2013. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Townamchai, Natavudh
Safa, Kassem
Chandraker, Anil
Immunologic monitoring in kidney transplant recipients
title Immunologic monitoring in kidney transplant recipients
title_full Immunologic monitoring in kidney transplant recipients
title_fullStr Immunologic monitoring in kidney transplant recipients
title_full_unstemmed Immunologic monitoring in kidney transplant recipients
title_short Immunologic monitoring in kidney transplant recipients
title_sort immunologic monitoring in kidney transplant recipients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713911/
https://www.ncbi.nlm.nih.gov/pubmed/26877913
http://dx.doi.org/10.1016/j.krcp.2013.04.002
work_keys_str_mv AT townamchainatavudh immunologicmonitoringinkidneytransplantrecipients
AT safakassem immunologicmonitoringinkidneytransplantrecipients
AT chandrakeranil immunologicmonitoringinkidneytransplantrecipients