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Two cases of idiopathic membranous nephropathy treated with rituximab
Idiopathic membranous nephropathy is a common cause of nephrotic syndrome, and has been reported as a cause of idiopathic primary glomerulonephropathy in up to 90% of patients. However, the treatment options remain controversial. We report two cases of idiopathic membranous nephropathy that were tre...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714091/ https://www.ncbi.nlm.nih.gov/pubmed/26877930 http://dx.doi.org/10.1016/j.krcp.2013.06.003 |
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author | Young Yoon, Jae Tae Han, Seung Cho, Ajin Ryoun Jang, Hye Eun Lee, Jung Huh, Wooseong Joong Kim, Dae Young Oh, Ha Kim, Yoon-Goo |
author_facet | Young Yoon, Jae Tae Han, Seung Cho, Ajin Ryoun Jang, Hye Eun Lee, Jung Huh, Wooseong Joong Kim, Dae Young Oh, Ha Kim, Yoon-Goo |
author_sort | Young Yoon, Jae |
collection | PubMed |
description | Idiopathic membranous nephropathy is a common cause of nephrotic syndrome, and has been reported as a cause of idiopathic primary glomerulonephropathy in up to 90% of patients. However, the treatment options remain controversial. We report two cases of idiopathic membranous nephropathy that were treated with rituximab. A 54-year-old man and a 64-year old man were admitted for rituximab therapy. They had previously been treated with combinations of immunosuppressive agents including cyclophosphamide, cyclosporine, mycophenolate, and steroids. However, the patients' heavy proteinuria was not resolved. Both patients received rituximab therapy, 2 weeks apart. After several months of follow-up and a second round of rituximab treatment for each patient, their proteinuria decreased and partial remission of disease was achieved in both patients. |
format | Online Article Text |
id | pubmed-4714091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-47140912016-02-12 Two cases of idiopathic membranous nephropathy treated with rituximab Young Yoon, Jae Tae Han, Seung Cho, Ajin Ryoun Jang, Hye Eun Lee, Jung Huh, Wooseong Joong Kim, Dae Young Oh, Ha Kim, Yoon-Goo Kidney Res Clin Pract Case Report Idiopathic membranous nephropathy is a common cause of nephrotic syndrome, and has been reported as a cause of idiopathic primary glomerulonephropathy in up to 90% of patients. However, the treatment options remain controversial. We report two cases of idiopathic membranous nephropathy that were treated with rituximab. A 54-year-old man and a 64-year old man were admitted for rituximab therapy. They had previously been treated with combinations of immunosuppressive agents including cyclophosphamide, cyclosporine, mycophenolate, and steroids. However, the patients' heavy proteinuria was not resolved. Both patients received rituximab therapy, 2 weeks apart. After several months of follow-up and a second round of rituximab treatment for each patient, their proteinuria decreased and partial remission of disease was achieved in both patients. Elsevier 2013-09 2013-07-17 /pmc/articles/PMC4714091/ /pubmed/26877930 http://dx.doi.org/10.1016/j.krcp.2013.06.003 Text en © 2013. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Young Yoon, Jae Tae Han, Seung Cho, Ajin Ryoun Jang, Hye Eun Lee, Jung Huh, Wooseong Joong Kim, Dae Young Oh, Ha Kim, Yoon-Goo Two cases of idiopathic membranous nephropathy treated with rituximab |
title | Two cases of idiopathic membranous nephropathy treated with rituximab |
title_full | Two cases of idiopathic membranous nephropathy treated with rituximab |
title_fullStr | Two cases of idiopathic membranous nephropathy treated with rituximab |
title_full_unstemmed | Two cases of idiopathic membranous nephropathy treated with rituximab |
title_short | Two cases of idiopathic membranous nephropathy treated with rituximab |
title_sort | two cases of idiopathic membranous nephropathy treated with rituximab |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714091/ https://www.ncbi.nlm.nih.gov/pubmed/26877930 http://dx.doi.org/10.1016/j.krcp.2013.06.003 |
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