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Treatment of phosphate retention: The earlier the better?
Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20(th) century that moderate hypercalcemia and hyperphosphatem...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714155/ https://www.ncbi.nlm.nih.gov/pubmed/26877944 http://dx.doi.org/10.1016/j.krcp.2013.11.004 |
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author | Biggar, Patrick Fung, Samuel K.S. Ketteler, Markus |
author_facet | Biggar, Patrick Fung, Samuel K.S. Ketteler, Markus |
author_sort | Biggar, Patrick |
collection | PubMed |
description | Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20(th) century that moderate hypercalcemia and hyperphosphatemia were acceptable in treating secondary hyperparathyroidism, the calcium and phosphate load is increasingly perceived to be a major trigger of vascular and soft tissue calcification. The current treatment options are discussed in view of historical developments and the expectations of the foreseeable future, focusing on the early treatment of hyperphosphatemia. At present, we lack indisputable evidence that active intervention using currently available drugs is of benefit to patients in chronic kidney disease stages 3 and 4. |
format | Online Article Text |
id | pubmed-4714155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-47141552016-02-12 Treatment of phosphate retention: The earlier the better? Biggar, Patrick Fung, Samuel K.S. Ketteler, Markus Kidney Res Clin Pract Review Article Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20(th) century that moderate hypercalcemia and hyperphosphatemia were acceptable in treating secondary hyperparathyroidism, the calcium and phosphate load is increasingly perceived to be a major trigger of vascular and soft tissue calcification. The current treatment options are discussed in view of historical developments and the expectations of the foreseeable future, focusing on the early treatment of hyperphosphatemia. At present, we lack indisputable evidence that active intervention using currently available drugs is of benefit to patients in chronic kidney disease stages 3 and 4. Elsevier 2014-03 2014-02-03 /pmc/articles/PMC4714155/ /pubmed/26877944 http://dx.doi.org/10.1016/j.krcp.2013.11.004 Text en © 2014. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Biggar, Patrick Fung, Samuel K.S. Ketteler, Markus Treatment of phosphate retention: The earlier the better? |
title | Treatment of phosphate retention: The earlier the better? |
title_full | Treatment of phosphate retention: The earlier the better? |
title_fullStr | Treatment of phosphate retention: The earlier the better? |
title_full_unstemmed | Treatment of phosphate retention: The earlier the better? |
title_short | Treatment of phosphate retention: The earlier the better? |
title_sort | treatment of phosphate retention: the earlier the better? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714155/ https://www.ncbi.nlm.nih.gov/pubmed/26877944 http://dx.doi.org/10.1016/j.krcp.2013.11.004 |
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