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Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome

Toxic epidermal necrolysis (TEN) is a drug-related fatal disease. Extensive necrosis of the epidermis can lead to serious complications. This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old ma...

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Detalles Bibliográficos
Autores principales: Lee, Eun Chae, Kim, Geun A, Koo, Ja Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714260/
https://www.ncbi.nlm.nih.gov/pubmed/26885481
http://dx.doi.org/10.1016/j.krcp.2014.08.002
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author Lee, Eun Chae
Kim, Geun A
Koo, Ja Wook
author_facet Lee, Eun Chae
Kim, Geun A
Koo, Ja Wook
author_sort Lee, Eun Chae
collection PubMed
description Toxic epidermal necrolysis (TEN) is a drug-related fatal disease. Extensive necrosis of the epidermis can lead to serious complications. This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lower extremities. Another case involved a 4-year-old boy receiving DFZ and enalapril. After a 41-day DFZ treatment period, erythematous papules appeared on the palms and soles. Within 3 days, both boys developed widespread skin lesions (>50%) and were admitted to the intensive care unit for resuscitative and supportive treatment. The patients showed improvement after intravenous immunoglobulin-G therapy. Owing to the rapid, fatal course of TEN, clinicians need to be aware of the adverse effects of this drug when treating cases of NS.
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spelling pubmed-47142602016-02-16 Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome Lee, Eun Chae Kim, Geun A Koo, Ja Wook Kidney Res Clin Pract Case Report Toxic epidermal necrolysis (TEN) is a drug-related fatal disease. Extensive necrosis of the epidermis can lead to serious complications. This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lower extremities. Another case involved a 4-year-old boy receiving DFZ and enalapril. After a 41-day DFZ treatment period, erythematous papules appeared on the palms and soles. Within 3 days, both boys developed widespread skin lesions (>50%) and were admitted to the intensive care unit for resuscitative and supportive treatment. The patients showed improvement after intravenous immunoglobulin-G therapy. Owing to the rapid, fatal course of TEN, clinicians need to be aware of the adverse effects of this drug when treating cases of NS. Elsevier 2014-12 2014-11-18 /pmc/articles/PMC4714260/ /pubmed/26885481 http://dx.doi.org/10.1016/j.krcp.2014.08.002 Text en © 2014. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Lee, Eun Chae
Kim, Geun A
Koo, Ja Wook
Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
title Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
title_full Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
title_fullStr Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
title_full_unstemmed Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
title_short Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
title_sort toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714260/
https://www.ncbi.nlm.nih.gov/pubmed/26885481
http://dx.doi.org/10.1016/j.krcp.2014.08.002
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