Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy

Li-Fraumeni Syndrome (LFS) is an autosomal dominant genetic disorder associated with mutations in the TP53 gene and characterized by a propensity to develop a variety of malignancies resulting in a shortened lifespan. We report a case of prostate cancer in a 50 year old male with LFS. Experimental s...

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Detalles Bibliográficos
Autores principales: Spees, Colleen K., Kelleher, Kelly J., Abaza, Ronney, Clinton, Steven K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714266/
https://www.ncbi.nlm.nih.gov/pubmed/26793489
http://dx.doi.org/10.1016/j.eucr.2015.01.002
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author Spees, Colleen K.
Kelleher, Kelly J.
Abaza, Ronney
Clinton, Steven K.
author_facet Spees, Colleen K.
Kelleher, Kelly J.
Abaza, Ronney
Clinton, Steven K.
author_sort Spees, Colleen K.
collection PubMed
description Li-Fraumeni Syndrome (LFS) is an autosomal dominant genetic disorder associated with mutations in the TP53 gene and characterized by a propensity to develop a variety of malignancies resulting in a shortened lifespan. We report a case of prostate cancer in a 50 year old male with LFS. Experimental studies suggest that TP53 mutations in prostate cancer are associated with therapeutic resistance to radiation, chemotherapy, and anti-androgens, implying that LFS men may experience more aggressive cancer biology with implications for therapeutic decisions. The potential of prostate cancer to develop earlier in LFS favors institution of screening at earlier ages.
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spelling pubmed-47142662016-01-20 Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy Spees, Colleen K. Kelleher, Kelly J. Abaza, Ronney Clinton, Steven K. Urol Case Rep Oncology Li-Fraumeni Syndrome (LFS) is an autosomal dominant genetic disorder associated with mutations in the TP53 gene and characterized by a propensity to develop a variety of malignancies resulting in a shortened lifespan. We report a case of prostate cancer in a 50 year old male with LFS. Experimental studies suggest that TP53 mutations in prostate cancer are associated with therapeutic resistance to radiation, chemotherapy, and anti-androgens, implying that LFS men may experience more aggressive cancer biology with implications for therapeutic decisions. The potential of prostate cancer to develop earlier in LFS favors institution of screening at earlier ages. Elsevier 2015-02-07 /pmc/articles/PMC4714266/ /pubmed/26793489 http://dx.doi.org/10.1016/j.eucr.2015.01.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Spees, Colleen K.
Kelleher, Kelly J.
Abaza, Ronney
Clinton, Steven K.
Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy
title Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy
title_full Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy
title_fullStr Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy
title_full_unstemmed Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy
title_short Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy
title_sort prostate cancer and li-fraumeni syndrome: implications for screening and therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714266/
https://www.ncbi.nlm.nih.gov/pubmed/26793489
http://dx.doi.org/10.1016/j.eucr.2015.01.002
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