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A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus

Aldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-producing adrenal adenoma and nephrogenic dia...

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Autores principales: Kim, Kitae, Lee, Jae Hyoung, Kim, Sun Chul, Cha, Dae Ryong, Kang, Young Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714286/
https://www.ncbi.nlm.nih.gov/pubmed/26885483
http://dx.doi.org/10.1016/j.krcp.2014.09.001
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author Kim, Kitae
Lee, Jae Hyoung
Kim, Sun Chul
Cha, Dae Ryong
Kang, Young Sun
author_facet Kim, Kitae
Lee, Jae Hyoung
Kim, Sun Chul
Cha, Dae Ryong
Kang, Young Sun
author_sort Kim, Kitae
collection PubMed
description Aldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-producing adrenal adenoma and nephrogenic diabetes insipidus. Aldosterone enhances the secretion of potassium in the collecting duct, which can lead to hypokalemia. By contrast, nephrogenic diabetes insipidus, which manifests as polyuria and polydipsia, can occur in several clinical conditions such as acquired tubular disease and those attributed to toxins and congenital causes. Among them, hypokalemia can also damage tubular structures in response to vasopressin. The patient’s urine output was >3 L/d and was diluted. Owing to the ineffectiveness of vasopressin, we eventually made a diagnosis of nephrogenic diabetes insipidus. Laparoscopic adrenalectomy and intraoperative kidney biopsy were subsequently performed. The pathologic finding of kidney biopsy revealed a decrease in aquaporin-2 on immunohistochemical stain.
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spelling pubmed-47142862016-02-16 A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus Kim, Kitae Lee, Jae Hyoung Kim, Sun Chul Cha, Dae Ryong Kang, Young Sun Kidney Res Clin Pract Case Report Aldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-producing adrenal adenoma and nephrogenic diabetes insipidus. Aldosterone enhances the secretion of potassium in the collecting duct, which can lead to hypokalemia. By contrast, nephrogenic diabetes insipidus, which manifests as polyuria and polydipsia, can occur in several clinical conditions such as acquired tubular disease and those attributed to toxins and congenital causes. Among them, hypokalemia can also damage tubular structures in response to vasopressin. The patient’s urine output was >3 L/d and was diluted. Owing to the ineffectiveness of vasopressin, we eventually made a diagnosis of nephrogenic diabetes insipidus. Laparoscopic adrenalectomy and intraoperative kidney biopsy were subsequently performed. The pathologic finding of kidney biopsy revealed a decrease in aquaporin-2 on immunohistochemical stain. Elsevier 2014-12 2014-11-26 /pmc/articles/PMC4714286/ /pubmed/26885483 http://dx.doi.org/10.1016/j.krcp.2014.09.001 Text en © 2014. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kim, Kitae
Lee, Jae Hyoung
Kim, Sun Chul
Cha, Dae Ryong
Kang, Young Sun
A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
title A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
title_full A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
title_fullStr A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
title_full_unstemmed A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
title_short A case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
title_sort case of primary aldosteronism combined with acquired nephrogenic diabetes insipidus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714286/
https://www.ncbi.nlm.nih.gov/pubmed/26885483
http://dx.doi.org/10.1016/j.krcp.2014.09.001
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