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Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation

Host genes that regulate systemic inflammation upon chronic viral infection are incompletely understood. Murine gammaherpesvirus 68 (MHV68) infection is characterized by latency in macrophages, and reactivation is inhibited by interferon-γ (IFN-γ). Using a lysozyme-M-cre (LysMcre) expression system,...

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Detalles Bibliográficos
Autores principales:	Park, Sunmin, Buck, Michael D., Desai, Chandni, Zhang, Xin, Loginicheva, Ekaterina, Martinez, Jennifer, Freeman, Michael L., Saitoh, Tatsuya, Akira, Shizuo, Guan, Jun-Lin, He, You-Wen, Blackman, Marcia A., Handley, Scott A., Levine, Beth, Green, Douglas R., Reese, Tiffany A., Artyomov, Maxim N., Virgin, Herbert W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714357/ https://www.ncbi.nlm.nih.gov/pubmed/26764599 http://dx.doi.org/10.1016/j.chom.2015.12.010

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