The Hydroxyl at Position C1 of Genipin Is the Active Inhibitory Group that Affects Mitochondrial Uncoupling Protein 2 in Panc-1 Cells

Genipin (GNP) effectively inhibits uncoupling protein 2 (UCP2), which regulates the leakage of protons across the inner mitochondrial membrane. UCP2 inhibition may induce pancreatic adenocarcinoma cell death by increasing reactive oxygen species (ROS) levels. In this study, the hydroxyls at position...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Yang, Yifu, Hou, Jianwei, Ding, Yue, Zhang, Tong, Zhang, Yong, Wang, Jianying, Shi, Chenchen, Fu, Wenwei, Cai, Zhenzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714807/
https://www.ncbi.nlm.nih.gov/pubmed/26771380
http://dx.doi.org/10.1371/journal.pone.0147026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714807/
https://www.ncbi.nlm.nih.gov/pubmed/26771380
http://dx.doi.org/10.1371/journal.pone.0147026

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