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Trophoblast-uterine interactions at implantation
Implantation of the embryo in the uterus is a critical and complex event and its failure is widely considered an impediment to improved success in assisted reproduction. Depending on whether placentation is invasive or superficial (epitheliochorial), the embryo may interact transiently or undergo a...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC471567/ https://www.ncbi.nlm.nih.gov/pubmed/15236654 http://dx.doi.org/10.1186/1477-7827-2-48 |
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author | Aplin, John D Kimber, Susan J |
author_facet | Aplin, John D Kimber, Susan J |
author_sort | Aplin, John D |
collection | PubMed |
description | Implantation of the embryo in the uterus is a critical and complex event and its failure is widely considered an impediment to improved success in assisted reproduction. Depending on whether placentation is invasive or superficial (epitheliochorial), the embryo may interact transiently or undergo a prolonged adhesive interaction with the uterine epithelium. Numerous candidate interactions have been identified, and there is good progress on identifying gene networks required for early placentation. However no molecular mechanisms for the epithelial phase are yet firmly established in any species. It is noteworthy that gene ablation in mice has so far failed to identify obligatory initial molecular events. |
format | Text |
id | pubmed-471567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-4715672004-07-17 Trophoblast-uterine interactions at implantation Aplin, John D Kimber, Susan J Reprod Biol Endocrinol Review Implantation of the embryo in the uterus is a critical and complex event and its failure is widely considered an impediment to improved success in assisted reproduction. Depending on whether placentation is invasive or superficial (epitheliochorial), the embryo may interact transiently or undergo a prolonged adhesive interaction with the uterine epithelium. Numerous candidate interactions have been identified, and there is good progress on identifying gene networks required for early placentation. However no molecular mechanisms for the epithelial phase are yet firmly established in any species. It is noteworthy that gene ablation in mice has so far failed to identify obligatory initial molecular events. BioMed Central 2004-07-05 /pmc/articles/PMC471567/ /pubmed/15236654 http://dx.doi.org/10.1186/1477-7827-2-48 Text en Copyright © 2004 Aplin and Kimber; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Review Aplin, John D Kimber, Susan J Trophoblast-uterine interactions at implantation |
title | Trophoblast-uterine interactions at implantation |
title_full | Trophoblast-uterine interactions at implantation |
title_fullStr | Trophoblast-uterine interactions at implantation |
title_full_unstemmed | Trophoblast-uterine interactions at implantation |
title_short | Trophoblast-uterine interactions at implantation |
title_sort | trophoblast-uterine interactions at implantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC471567/ https://www.ncbi.nlm.nih.gov/pubmed/15236654 http://dx.doi.org/10.1186/1477-7827-2-48 |
work_keys_str_mv | AT aplinjohnd trophoblastuterineinteractionsatimplantation AT kimbersusanj trophoblastuterineinteractionsatimplantation |