A case of membranous nephropathy as a manifestation of graft-versus-host disease

Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT...

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Detalles Bibliográficos
Autores principales: Han, Jae Hyun, Kim, Hyoung Rae, Kim, Gi Jeong, Lim, Beom Jin, Jeong, Hyeon Joo, Oh, Hyung Jung, Yoo, Tae-Hyun, Kang, Shin-Wook, Choi, Kyu Hun, Han, Seung Hyeok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716117/
https://www.ncbi.nlm.nih.gov/pubmed/26889436
http://dx.doi.org/10.1016/j.krcp.2012.09.008
Descripción
Sumario:Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT from her human leukocyte antigen-identical brother following myeloablative conditioning chemotherapy. NS occurred 21 months after HSCT without any concurrent features of chronic GVHD. The patient was treated with prednisolone and cyclosporine after renal biopsy confirmed membranous nephropathy, and achieved complete remission. Our report contradicts previous assumptions that concomitant chronic GVHD is responsible for the development of NS, suggesting that NS can develop as a new, independent manifestation of GVHD.

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