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A case of membranous nephropathy as a manifestation of graft-versus-host disease
Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716117/ https://www.ncbi.nlm.nih.gov/pubmed/26889436 http://dx.doi.org/10.1016/j.krcp.2012.09.008 |
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author | Han, Jae Hyun Kim, Hyoung Rae Kim, Gi Jeong Lim, Beom Jin Jeong, Hyeon Joo Oh, Hyung Jung Yoo, Tae-Hyun Kang, Shin-Wook Choi, Kyu Hun Han, Seung Hyeok |
author_facet | Han, Jae Hyun Kim, Hyoung Rae Kim, Gi Jeong Lim, Beom Jin Jeong, Hyeon Joo Oh, Hyung Jung Yoo, Tae-Hyun Kang, Shin-Wook Choi, Kyu Hun Han, Seung Hyeok |
author_sort | Han, Jae Hyun |
collection | PubMed |
description | Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT from her human leukocyte antigen-identical brother following myeloablative conditioning chemotherapy. NS occurred 21 months after HSCT without any concurrent features of chronic GVHD. The patient was treated with prednisolone and cyclosporine after renal biopsy confirmed membranous nephropathy, and achieved complete remission. Our report contradicts previous assumptions that concomitant chronic GVHD is responsible for the development of NS, suggesting that NS can develop as a new, independent manifestation of GVHD. |
format | Online Article Text |
id | pubmed-4716117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-47161172016-02-17 A case of membranous nephropathy as a manifestation of graft-versus-host disease Han, Jae Hyun Kim, Hyoung Rae Kim, Gi Jeong Lim, Beom Jin Jeong, Hyeon Joo Oh, Hyung Jung Yoo, Tae-Hyun Kang, Shin-Wook Choi, Kyu Hun Han, Seung Hyeok Kidney Res Clin Pract Case Report Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT from her human leukocyte antigen-identical brother following myeloablative conditioning chemotherapy. NS occurred 21 months after HSCT without any concurrent features of chronic GVHD. The patient was treated with prednisolone and cyclosporine after renal biopsy confirmed membranous nephropathy, and achieved complete remission. Our report contradicts previous assumptions that concomitant chronic GVHD is responsible for the development of NS, suggesting that NS can develop as a new, independent manifestation of GVHD. Elsevier 2013-03 2012-10-15 /pmc/articles/PMC4716117/ /pubmed/26889436 http://dx.doi.org/10.1016/j.krcp.2012.09.008 Text en © 2013. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Han, Jae Hyun Kim, Hyoung Rae Kim, Gi Jeong Lim, Beom Jin Jeong, Hyeon Joo Oh, Hyung Jung Yoo, Tae-Hyun Kang, Shin-Wook Choi, Kyu Hun Han, Seung Hyeok A case of membranous nephropathy as a manifestation of graft-versus-host disease |
title | A case of membranous nephropathy as a manifestation of graft-versus-host disease |
title_full | A case of membranous nephropathy as a manifestation of graft-versus-host disease |
title_fullStr | A case of membranous nephropathy as a manifestation of graft-versus-host disease |
title_full_unstemmed | A case of membranous nephropathy as a manifestation of graft-versus-host disease |
title_short | A case of membranous nephropathy as a manifestation of graft-versus-host disease |
title_sort | case of membranous nephropathy as a manifestation of graft-versus-host disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716117/ https://www.ncbi.nlm.nih.gov/pubmed/26889436 http://dx.doi.org/10.1016/j.krcp.2012.09.008 |
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