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Endothelium-dependent vasodilation by ferulic acid in aorta from chronic renal hypertensive rats

BACKGROUND: Ferulic acid (FA) is a naturally occurring nutritional compound. Although it has been shown to have antihypertensive effects, its effects on vascular function have not been intensively established. The aim of this study was to assess the vasoreactivity of FA in chronic two-kidney, one-cl...

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Autores principales: Choi, Seok, Il Kim, Hyun, Hag Park, Sang, Jung Lee, Mi, Yeoul Jun, Jae, Lee Kim, Hyun, Hoon Chung, Jong, Ho Yeum, Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716118/
https://www.ncbi.nlm.nih.gov/pubmed/26889426
http://dx.doi.org/10.1016/j.krcp.2012.09.001
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author Choi, Seok
Il Kim, Hyun
Hag Park, Sang
Jung Lee, Mi
Yeoul Jun, Jae
Lee Kim, Hyun
Hoon Chung, Jong
Ho Yeum, Cheol
author_facet Choi, Seok
Il Kim, Hyun
Hag Park, Sang
Jung Lee, Mi
Yeoul Jun, Jae
Lee Kim, Hyun
Hoon Chung, Jong
Ho Yeum, Cheol
author_sort Choi, Seok
collection PubMed
description BACKGROUND: Ferulic acid (FA) is a naturally occurring nutritional compound. Although it has been shown to have antihypertensive effects, its effects on vascular function have not been intensively established. The aim of this study was to assess the vasoreactivity of FA in chronic two-kidney, one-clip (2K1C) renal hypertensive rats. METHODS: Hypertension was induced in 2K1C rats by clipping the left renal artery and age-matched rats that received a sham treatment served as a control. Thoracic aortas were mounted in tissue baths to measure isometric tension. The effects of FA on vasodilatory responses were evaluated based on contractile responses induced by phenylephrine in the aortic rings obtained from both 2K1C and sham rats. Basal nitric oxide (NO) bioavailability in the aorta was determined by the contractile response induced by NO synthase inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME). RESULTS: FA induced concentration-dependent relaxation responses which were greater in 2K1C hypertensive rats than in sham-clipped control rats. This relaxation induced by FA was partially blocked by the removal of endothelium or by pretreating with l-NAME. l-NAME-induced contractile responses were augmented by FA in 2K1C rats, while no significant differences were noted in sham rats. FA improved acetylcholine-induced endothelium-dependent vasodilation in 2K1C rats, but not in sham rats. The simultaneous addition of hydroxyhydroquinone significantly inhibited the increase in acetylcholine-induced vasodilation by FA. CONCLUSION: These results suggest that FA restores endothelial function by altering the bioavailability of NO in 2K1C hypertensive rats. The results explain, in part, the mechanism underlying the vascular effects of FA in chronic renal hypertension.
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spelling pubmed-47161182016-02-17 Endothelium-dependent vasodilation by ferulic acid in aorta from chronic renal hypertensive rats Choi, Seok Il Kim, Hyun Hag Park, Sang Jung Lee, Mi Yeoul Jun, Jae Lee Kim, Hyun Hoon Chung, Jong Ho Yeum, Cheol Kidney Res Clin Pract Original Article BACKGROUND: Ferulic acid (FA) is a naturally occurring nutritional compound. Although it has been shown to have antihypertensive effects, its effects on vascular function have not been intensively established. The aim of this study was to assess the vasoreactivity of FA in chronic two-kidney, one-clip (2K1C) renal hypertensive rats. METHODS: Hypertension was induced in 2K1C rats by clipping the left renal artery and age-matched rats that received a sham treatment served as a control. Thoracic aortas were mounted in tissue baths to measure isometric tension. The effects of FA on vasodilatory responses were evaluated based on contractile responses induced by phenylephrine in the aortic rings obtained from both 2K1C and sham rats. Basal nitric oxide (NO) bioavailability in the aorta was determined by the contractile response induced by NO synthase inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME). RESULTS: FA induced concentration-dependent relaxation responses which were greater in 2K1C hypertensive rats than in sham-clipped control rats. This relaxation induced by FA was partially blocked by the removal of endothelium or by pretreating with l-NAME. l-NAME-induced contractile responses were augmented by FA in 2K1C rats, while no significant differences were noted in sham rats. FA improved acetylcholine-induced endothelium-dependent vasodilation in 2K1C rats, but not in sham rats. The simultaneous addition of hydroxyhydroquinone significantly inhibited the increase in acetylcholine-induced vasodilation by FA. CONCLUSION: These results suggest that FA restores endothelial function by altering the bioavailability of NO in 2K1C hypertensive rats. The results explain, in part, the mechanism underlying the vascular effects of FA in chronic renal hypertension. Elsevier 2012-12 2012-09-21 /pmc/articles/PMC4716118/ /pubmed/26889426 http://dx.doi.org/10.1016/j.krcp.2012.09.001 Text en © 2012. The Korean Society of Nephrology. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Choi, Seok
Il Kim, Hyun
Hag Park, Sang
Jung Lee, Mi
Yeoul Jun, Jae
Lee Kim, Hyun
Hoon Chung, Jong
Ho Yeum, Cheol
Endothelium-dependent vasodilation by ferulic acid in aorta from chronic renal hypertensive rats
title Endothelium-dependent vasodilation by ferulic acid in aorta from chronic renal hypertensive rats
title_full Endothelium-dependent vasodilation by ferulic acid in aorta from chronic renal hypertensive rats
title_fullStr Endothelium-dependent vasodilation by ferulic acid in aorta from chronic renal hypertensive rats
title_full_unstemmed Endothelium-dependent vasodilation by ferulic acid in aorta from chronic renal hypertensive rats
title_short Endothelium-dependent vasodilation by ferulic acid in aorta from chronic renal hypertensive rats
title_sort endothelium-dependent vasodilation by ferulic acid in aorta from chronic renal hypertensive rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716118/
https://www.ncbi.nlm.nih.gov/pubmed/26889426
http://dx.doi.org/10.1016/j.krcp.2012.09.001
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