Cargando…

Phase 2, randomised placebo-controlled trial to evaluate the efficacy and safety of an anti-GM-CSF antibody (KB003) in patients with inadequately controlled asthma

OBJECTIVES: We wished to evaluate the effects of an antigranulocyte-macrophage colony-stimulating factor monoclonal antibody (KB003) on forced expiratory volume in 1 s (FEV(1)), asthma control and asthma exacerbations in adult asthmatics inadequately controlled by long-acting bronchodilators and inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Molfino, Nestor A, Kuna, Piotr, Leff, Jonathan A, Oh, Chad K, Singh, Dave, Chernow, Marlene, Sutton, Brian, Yarranton, Geoffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Respiratory Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716197/ https://www.ncbi.nlm.nih.gov/pubmed/26739717 http://dx.doi.org/10.1136/bmjopen-2015-007709

Ejemplares similares

Effect of vitamin D(3) on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial
por: Vargas Buonfiglio, Luis G, et al.
Publicado: (2017)

Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults
por: Ioannides, Sally J, et al.
Publicado: (2014)

Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies
por: Hanania, Nicola A, et al.
Publicado: (2015)

Behaviour-change intervention in a multicentre, randomised, placebo-controlled COPD study: methodological considerations and implementation
por: Bourbeau, Jean, et al.
Publicado: (2016)

Effect of acetazolamide on obstructive sleep apnoea in highlanders: protocol for a randomised, placebo-controlled, double-blinded crossover trial
por: Tan, Lu, et al.
Publicado: (2022)

The impact of exacerbation frequency on mortality following acute exacerbations of COPD: a registry-based cohort study
por: Schmidt, Sigrun Alba Johannesdottir, et al.
Publicado: (2014)

Preventing adverse cardiac events (PACE) in chronic obstructive pulmonary disease (COPD): study protocol for a double-blind, placebo controlled, randomised controlled trial of bisoprolol in COPD
por: Martin, Allison, et al.
Publicado: (2021)

RCT of the effect of berryfruit polyphenolic cultivar extract in mild steroid-naive asthma: a cross-over, placebo-controlled study
por: Power, Sharon, et al.
Publicado: (2017)

Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): protocol for a multicentre randomised placebo-controlled triple-blind trial
por: Jensen, Megan E, et al.
Publicado: (2019)

Dual bronchodilators in Bronchiectasis study (DIBS): protocol for a pragmatic, multicentre, placebo-controlled, three-arm, double-blinded, randomised controlled trial studying bronchodilators in preventing exacerbations of bronchiectasis
por: Morton, Miranda, et al.
Publicado: (2023)

Enhancing exercise tolerance and physical activity in COPD with combined pharmacological and non-pharmacological interventions: PHYSACTO randomised, placebo-controlled study design
por: Troosters, Thierry, et al.
Publicado: (2016)

Efficacy and safety of GHX02 in the treatment of acute bronchitis: protocol of a phase II, double-blind, randomised placebo-controlled trial
por: Lyu, Yee Ran, et al.
Publicado: (2018)

Shufeng Jiedu capsule for acute exacerbation of chronic obstructive pulmonary disease: a protocol of multicentre, randomised, double-blind, placebo-controlled trial
por: Xia, Ruyu, et al.
Publicado: (2023)

Design of a phase III, double-blind, randomised, placebo-controlled trial of BI 1015550 in patients with idiopathic pulmonary fibrosis (FIBRONEER-IPF)
por: Richeldi, Luca, et al.
Publicado: (2023)

GM-CSF in inflammation
por: Hamilton, John A.
Publicado: (2019)

Efficacy and safety of 4 weeks' treatment with combined fluticasone furoate/vilanterol in a single inhaler given once daily in COPD: a placebo-controlled randomised trial
por: Lötvall, J, et al.
Publicado: (2012)

Study protocol for a randomised, placebo-controlled, single-blind phase II study of the efficacy of morphine for dyspnoea in patients with interstitial lung disease (JORTC-PAL 15)
por: Matsuda, Yoshinobu, et al.
Publicado: (2021)

G-CSF and GM-CSF in clinical trials.
por: Antman, K. H.
Publicado: (1990)

Study protocol: azithromycin therapy for chronic lung disease of prematurity (AZTEC) - a randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants
por: Lowe, John, et al.
Publicado: (2020)

Adherence-adjusted estimates of benefits and harms from treatment with amoxicillin for LRTI: secondary analysis of a 12-country randomised placebo-controlled trial using randomisation-based efficacy estimators
por: Gillespie, David, et al.
Publicado: (2015)

Prophylactic epinephrine for the prevention of transbronchial lung biopsy-related bleeding in lung transplant recipients (PROPHET) study: a protocol for a multicentre randomised, double-blind, placebo-controlled trial
por: Kalchiem-Dekel, Or, et al.
Publicado: (2019)

Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)
por: Taylor, Peter C, et al.
Publicado: (2023)

GM-CSF Dependent Differential Control of Mycobacterium tuberculosis Infection in Human and Mouse Macrophages: Is Macrophage Source of GM-CSF Critical to Tuberculosis Immunity?
por: Mishra, Abhishek, et al.
Publicado: (2020)

Quality of life, healthcare use and costs in ‘at-risk’ children after early antibiotic treatment versus placebo for influenza-like illness: within-trial descriptive economic analyses of the ARCHIE randomised controlled trial
por: Rombach, Ines, et al.
Publicado: (2022)

Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders
por: Lazarus, Hillard M., et al.
Publicado: (2023)

iNKT Cell Production of GM-CSF Controls Mycobacterium tuberculosis
por: Rothchild, Alissa C., et al.
Publicado: (2014)

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
por: Bryson, Bryan D., et al.
Publicado: (2019)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

GM-CSF-Dependent Inflammatory Pathways
por: Hamilton, John A.
Publicado: (2019)

Development of Dendritic Cells from GM-CSF(-/-) Mice in vitro : GM-CSF Enhances Production and Survival of Cells
por: Ni, Keping, et al.
Publicado: (2001)

Theory-based self-management intervention to improve adolescents’ asthma control: a cluster randomised controlled trial protocol
por: Harris, Katherine, et al.
Publicado: (2019)

Effect of aerobic exercise training on asthma control in postmenopausal women (the ATOM-study): protocol for an outcome assessor, randomised controlled trial
por: Hansen, Erik Sören Halvard, et al.
Publicado: (2021)

Inhibition of bradykinin in SARS-CoV-2 infection: a randomised, double-blind trial of icatibant compared with placebo (ICASARS)
por: Bailey, Melanie, et al.
Publicado: (2023)

Statin use and asthma control in patients with severe asthma
por: Zeki, Amir A, et al.
Publicado: (2013)

Randomised controlled trial of vitamin D supplementation in sarcoidosis
por: Bolland, Mark J, et al.
Publicado: (2013)

Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF(+) T Lymphocytes
por: Bystrom, Jonas, et al.
Publicado: (2017)

Construction of Recombinant Human GM-CSF and GM-CSF-ApoA-I Fusion Protein and Evaluation of Their Biological Activity
por: Pykhtina, Mariya, et al.
Publicado: (2021)

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
por: Piper, Edward, et al.
Publicado: (2013)

Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis
por: Pinder, Emma M, et al.
Publicado: (2018)

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation
por: Shiomi, Aoi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vc17l0rqeapiaevdsh7c1vlf8g