The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress

The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/or degenerative neuronal defects, the pathoge...

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Detalles Bibliográficos
Autores principales: Petroni, M, Sardina, F, Heil, C, Sahún-Roncero, M, Colicchia, V, Veschi, V, Albini, S, Fruci, D, Ricci, B, Soriani, A, Di Marcotullio, L, Screpanti, I, Gulino, A, Giannini, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716299/
https://www.ncbi.nlm.nih.gov/pubmed/26068589
http://dx.doi.org/10.1038/cdd.2015.81

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