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Effect of collagen sponge and fibrin glue on bone repair

The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. OBJECTIVE: In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat cal...

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Autores principales: SANTOS, Thiago de Santana, ABUNA, Rodrigo Paolo Flores, de ALMEIDA, Adriana Luisa Gonçalves, BELOTI, Marcio Mateus, ROSA, Adalberto Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Odontologia de Bauru da Universidade de São Paulo 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716700/
https://www.ncbi.nlm.nih.gov/pubmed/26814464
http://dx.doi.org/10.1590/1678-775720150374
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author SANTOS, Thiago de Santana
ABUNA, Rodrigo Paolo Flores
de ALMEIDA, Adriana Luisa Gonçalves
BELOTI, Marcio Mateus
ROSA, Adalberto Luiz
author_facet SANTOS, Thiago de Santana
ABUNA, Rodrigo Paolo Flores
de ALMEIDA, Adriana Luisa Gonçalves
BELOTI, Marcio Mateus
ROSA, Adalberto Luiz
author_sort SANTOS, Thiago de Santana
collection PubMed
description The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. OBJECTIVE: In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. MATERIAL AND METHODS: Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). RESULTS: Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. CONCLUSION: Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous.
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spelling pubmed-47167002016-01-20 Effect of collagen sponge and fibrin glue on bone repair SANTOS, Thiago de Santana ABUNA, Rodrigo Paolo Flores de ALMEIDA, Adriana Luisa Gonçalves BELOTI, Marcio Mateus ROSA, Adalberto Luiz J Appl Oral Sci Original Articles The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. OBJECTIVE: In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. MATERIAL AND METHODS: Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). RESULTS: Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. CONCLUSION: Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous. Faculdade de Odontologia de Bauru da Universidade de São Paulo 2015 /pmc/articles/PMC4716700/ /pubmed/26814464 http://dx.doi.org/10.1590/1678-775720150374 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
SANTOS, Thiago de Santana
ABUNA, Rodrigo Paolo Flores
de ALMEIDA, Adriana Luisa Gonçalves
BELOTI, Marcio Mateus
ROSA, Adalberto Luiz
Effect of collagen sponge and fibrin glue on bone repair
title Effect of collagen sponge and fibrin glue on bone repair
title_full Effect of collagen sponge and fibrin glue on bone repair
title_fullStr Effect of collagen sponge and fibrin glue on bone repair
title_full_unstemmed Effect of collagen sponge and fibrin glue on bone repair
title_short Effect of collagen sponge and fibrin glue on bone repair
title_sort effect of collagen sponge and fibrin glue on bone repair
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716700/
https://www.ncbi.nlm.nih.gov/pubmed/26814464
http://dx.doi.org/10.1590/1678-775720150374
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