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Effect of collagen sponge and fibrin glue on bone repair
The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. OBJECTIVE: In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat cal...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculdade de Odontologia de Bauru da Universidade de São Paulo
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716700/ https://www.ncbi.nlm.nih.gov/pubmed/26814464 http://dx.doi.org/10.1590/1678-775720150374 |
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author | SANTOS, Thiago de Santana ABUNA, Rodrigo Paolo Flores de ALMEIDA, Adriana Luisa Gonçalves BELOTI, Marcio Mateus ROSA, Adalberto Luiz |
author_facet | SANTOS, Thiago de Santana ABUNA, Rodrigo Paolo Flores de ALMEIDA, Adriana Luisa Gonçalves BELOTI, Marcio Mateus ROSA, Adalberto Luiz |
author_sort | SANTOS, Thiago de Santana |
collection | PubMed |
description | The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. OBJECTIVE: In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. MATERIAL AND METHODS: Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). RESULTS: Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. CONCLUSION: Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous. |
format | Online Article Text |
id | pubmed-4716700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Faculdade de Odontologia de Bauru da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-47167002016-01-20 Effect of collagen sponge and fibrin glue on bone repair SANTOS, Thiago de Santana ABUNA, Rodrigo Paolo Flores de ALMEIDA, Adriana Luisa Gonçalves BELOTI, Marcio Mateus ROSA, Adalberto Luiz J Appl Oral Sci Original Articles The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. OBJECTIVE: In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. MATERIAL AND METHODS: Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). RESULTS: Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. CONCLUSION: Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous. Faculdade de Odontologia de Bauru da Universidade de São Paulo 2015 /pmc/articles/PMC4716700/ /pubmed/26814464 http://dx.doi.org/10.1590/1678-775720150374 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles SANTOS, Thiago de Santana ABUNA, Rodrigo Paolo Flores de ALMEIDA, Adriana Luisa Gonçalves BELOTI, Marcio Mateus ROSA, Adalberto Luiz Effect of collagen sponge and fibrin glue on bone repair |
title | Effect of collagen sponge and fibrin glue on bone repair |
title_full | Effect of collagen sponge and fibrin glue on bone repair |
title_fullStr | Effect of collagen sponge and fibrin glue on bone repair |
title_full_unstemmed | Effect of collagen sponge and fibrin glue on bone repair |
title_short | Effect of collagen sponge and fibrin glue on bone repair |
title_sort | effect of collagen sponge and fibrin glue on bone repair |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716700/ https://www.ncbi.nlm.nih.gov/pubmed/26814464 http://dx.doi.org/10.1590/1678-775720150374 |
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