Cargando…

Neuroprotective effects of 20(S)-protopanaxadiol against glutamate-induced mitochondrial dysfunction in PC12 cells

Ginseng (Panax ginseng C.A. Mey.) is commonly used in traditional oriental medicine for its wide spectrum of medicinal properties, including anti-inflammatory, antitumorigenic, adaptogenic and anti-aging properties. 20(S)-Protopanaxadiol (PPD), the main intestinal metabolite of ginsenosides, is one...

Descripción completa

Detalles Bibliográficos
Autores principales:	BAK, DONG-HO, KIM, HYUNG DON, KIM, YOUNG OCK, PARK, CHUN GEUN, HAN, SEUNG-YUN, KIM, JWA-JIN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716797/ https://www.ncbi.nlm.nih.gov/pubmed/26709399 http://dx.doi.org/10.3892/ijmm.2015.2440

Ejemplares similares

Phlorofucofuroeckol Improves Glutamate-Induced Neurotoxicity through Modulation of Oxidative Stress-Mediated Mitochondrial Dysfunction in PC12 Cells
por: Kim, Jwa-Jin, et al.
Publicado: (2016)

Formulation And Evaluation Of Nanostructured Lipid Carriers (NLCs) Of 20(S)-Protopanaxadiol (PPD) By Box-Behnken Design
por: Kim, Min-Hwan, et al.
Publicado: (2019)

Paeoniflorin exerts neuroprotective effects against glutamate-induced PC12 cellular cytotoxicity by inhibiting apoptosis
por: Chen, Ahong, et al.
Publicado: (2017)

Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction
por: Chen, Feiyan, et al.
Publicado: (2023)

Synergistic production of 20(S)-protopanaxadiol from protopanaxadiol-type ginsenosides by β-glycosidases from Dictyoglomus turgidum and Caldicellulosiruptor bescii
por: Choi, Ji-Hyeon, et al.
Publicado: (2017)

Development of 20(S)-Protopanaxadiol-Loaded SNEDDS Preconcentrate Using Comprehensive Phase Diagram for the Enhanced Dissolution and Oral Bioavailability
por: Kim, Young Hoon, et al.
Publicado: (2020)

The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model
por: Zhang, Junrong, et al.
Publicado: (2016)

20(S)-Protopanaxadiol saponins inhibit SKOV3 cell migration
por: LI, BIN, et al.
Publicado: (2016)

The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells
por: Park, Kum Ju, et al.
Publicado: (2007)

Computational and experimental characterization of estrogenic activities of 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol
por: Zhang, Tiehua, et al.
Publicado: (2020)

20(S)-Protopanaxadiol Inhibition of Progression and Growth of Castration-Resistant Prostate Cancer
por: Cao, Bo, et al.
Publicado: (2014)

Rerouting of NADPH synthetic pathways for increased protopanaxadiol production in Saccharomyces cerevisiae
por: Kim, Jae-Eung, et al.
Publicado: (2018)

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells
por: Wu, Chuanhong, et al.
Publicado: (2018)

Microemulsion-based hydrogels for enhancing epidermal/dermal deposition of topically administered 20(S)-protopanaxadiol: in vitro and in vivo evaluation studies
por: Kim, Ki-Taek, et al.
Publicado: (2018)

Characterization, Molecular Docking, and In Vitro Dissolution Studies of Solid Dispersions of 20(S)-Protopanaxadiol
por: Zhang, Qi, et al.
Publicado: (2017)

Astaxanthin Protects PC12 Cells against Homocysteine- and Glutamate-Induced Neurotoxicity
por: Chang, Chi-Huang, et al.
Publicado: (2020)

Neuroprotective Effects of Biochanin A against β-Amyloid-Induced Neurotoxicity in PC12 Cells via a Mitochondrial-Dependent Apoptosis Pathway
por: Tan, Ji Wei, et al.
Publicado: (2016)

ERKs and mitochondria-related pathways are essential for glycyrrhizic acid-mediated neuroprotection against glutamate-induced toxicity in differentiated PC12 cells
por: Wang, D., et al.
Publicado: (2014)

Predicting a Potential Link to Antidepressant Effect: Neuroprotection of Zhi-zi-chi Decoction on Glutamate-induced Cytotoxicity in PC12 Cells
por: Zhang, Yin, et al.
Publicado: (2021)

A 20(S)-protopanaxadiol derivative PPD12 reverses ABCB1-mediated multidrug resistance with oral bioavailability and low toxicity
por: Wei, Shunfeng, et al.
Publicado: (2018)

Beneficial effects of 20(S)-protopanaxadiol on antitumor activity and toxicity of cyclophosphamide in tumor-bearing mice
por: LIN, GUANGZHU, et al.
Publicado: (2013)

Polycaprolactone nanofibres loaded with 20(S)-protopanaxadiol for in vitro and in vivo anti-tumour activity study
por: Liu, Dan-qing, et al.
Publicado: (2018)

The Ginsenoside 20-O-β-D-Glucopyranosyl-20(S)-Protopanaxadiol Induces Autophagy and Apoptosis in Human Melanoma via AMPK/JNK Phosphorylation
por: Kang, Soouk, et al.
Publicado: (2014)

Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells
por: Park, Bonggoo, et al.
Publicado: (2013)

Effects of phenolic constituents of daylily flowers on corticosterone- and glutamate-treated PC12 cells
por: Tian, Huan, et al.
Publicado: (2017)

Neuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction
por: Jeong, Ji Heun, et al.
Publicado: (2018)

Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways
por: GAO, JIAN-LI, et al.
Publicado: (2013)

Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress
por: ALNasser, Maryam N., et al.
Publicado: (2023)

Hericium Erinaceus Prevents DEHP-Induced Mitochondrial Dysfunction and Apoptosis in PC12 Cells
por: Amara, Ines, et al.
Publicado: (2020)

Neuroprotective Effects of Exogenous Activin A on Oxygen-Glucose Deprivation in PC12 Cells
por: He, Jin-Ting, et al.
Publicado: (2011)

Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions
por: Yang, Yanyan, et al.
Publicado: (2014)

Effect of Ginseng Sapogenin Protopanaxadiol-Enriched Rice (DJ-PPD) on Immunomodulation
por: Monmai, Chaiwat, et al.
Publicado: (2023)

20(S)-Protopanaxadiol Phospholipid Complex: Process Optimization, Characterization, In Vitro Dissolution and Molecular Docking Studies
por: Pu, Yiqiong, et al.
Publicado: (2016)

20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1
por: Wang, Yuchen, et al.
Publicado: (2019)

Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis
por: Jo, Hantae, et al.
Publicado: (2021)

The anti-tumor efficacy of 20(S)-protopanaxadiol, an active metabolite of ginseng, according to fasting on hepatocellular carcinoma
por: Li, Wenzhen, et al.
Publicado: (2022)

Ginseng saponin metabolite 20(S)-protopanaxadiol relieves pulmonary fibrosis by multiple-targets signaling pathways
por: Ren, Guoqing, et al.
Publicado: (2023)

20-O-β-d-Xylopyranosyl(1→6)-β-d-glucopyranosyl-20(S)-protopanaxadiol methanol solvate
por: Li, Xing-Wei, et al.
Publicado: (2007)

Comparison of the Effects of Yokukansan and Yokukansankachimpihange on Glutamate Uptake by Cultured Astrocytes and Glutamate-Induced Excitotoxicity in Cultured PC12 Cells
por: Kawakami, Zenji, et al.
Publicado: (2019)

Low Doses of Camptothecin Induced Hormetic and Neuroprotective Effects in PC12 Cells
por: Zhang, Chao, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_rdq3n8m977ivkas8nct2tat3mk