A spontaneous increase in intracellular Ca(2+) in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K(+) channels

STUDY QUESTION: Could drugs targeting ATP-sensitive K(+) (K(ATP)) channels prevent any spontaneous increase in intracellular Ca(2+) that may occur in human metaphase II (MII) oocytes under in vitro conditions? SUMMARY ANSWER: Pinacidil, a K(ATP) channel opener, and glibenclamide, a K(ATP) channel bl...

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Detalles Bibliográficos
Autores principales: Fernandes, Gonçalo, Dasai, Navin, Kozlova, Natalia, Mojadadi, Albaraa, Gall, Mandy, Drew, Ellen, Barratt, Evelyn, Madamidola, Oladipo A., Brown, Sean G., Milne, Alison M., Martins da Silva, Sarah J., Whalley, Katherine M., Barratt, Christopher L.R., Jovanović, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716808/
https://www.ncbi.nlm.nih.gov/pubmed/26682579
http://dx.doi.org/10.1093/humrep/dev300

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