Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer

Whole-genome and transcriptome sequencing were used to discover novel gene fusions in a case of colon cancer. A tumor-specific LACTB2-NCOA2 fusion originating from intra-chromosomal rearrangement of chromosome 8 was identified at both DNA and RNA levels. Unlike conventional oncogenic chimeric protei...

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Detalles Bibliográficos
Autores principales: Yu, J, Wu, W K K, Liang, Q, Zhang, N, He, J, Li, X, Zhang, X, Xu, L, Chan, M T V, Ng, S S M, Sung, J J Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717154/
https://www.ncbi.nlm.nih.gov/pubmed/25823027
http://dx.doi.org/10.1038/onc.2015.72

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