2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors

A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (A...

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Autores principales: Babkov, D. A., Paramonova, M. P., Ozerov, A. A., Khandazhinskaya, A. L., Snoeck, R., Andrei, G., Novikov, M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717260/
https://www.ncbi.nlm.nih.gov/pubmed/26798502
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author Babkov, D. A.
Paramonova, M. P.
Ozerov, A. A.
Khandazhinskaya, A. L.
Snoeck, R.
Andrei, G.
Novikov, M. S.
author_facet Babkov, D. A.
Paramonova, M. P.
Ozerov, A. A.
Khandazhinskaya, A. L.
Snoeck, R.
Andrei, G.
Novikov, M. S.
author_sort Babkov, D. A.
collection PubMed
description A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (AD-169 and Davis strains) in HEL cell cultures. In addition, some of the derivatives proved to be inhibitory against varicella zoster virus.
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spelling pubmed-47172602016-01-21 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors Babkov, D. A. Paramonova, M. P. Ozerov, A. A. Khandazhinskaya, A. L. Snoeck, R. Andrei, G. Novikov, M. S. Acta Naturae Research Article A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (AD-169 and Davis strains) in HEL cell cultures. In addition, some of the derivatives proved to be inhibitory against varicella zoster virus. A.I. Gordeyev 2015 /pmc/articles/PMC4717260/ /pubmed/26798502 Text en Copyright ® 2015 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Babkov, D. A.
Paramonova, M. P.
Ozerov, A. A.
Khandazhinskaya, A. L.
Snoeck, R.
Andrei, G.
Novikov, M. S.
2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors
title 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors
title_full 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors
title_fullStr 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors
title_full_unstemmed 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors
title_short 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors
title_sort 2-(2,4-dioxy-1,2,3,4-tetrahydropyrimidin-1-yl)-n-(4-phenoxyphenyl)-acetamides as a novel class of cytomegalovirus replication inhibitors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717260/
https://www.ncbi.nlm.nih.gov/pubmed/26798502
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